Synthesis and pharmacology of some new N,N-disubstituted dithiocarbamate derivatives

In this study, twenty two new N,N-disubstituted dithiocarbamate derivatives were synthesized. The structures of the compounds were confirmed by IR, 1H-NMR, mass spectroscopy and elemental analysis. Anticholinergic activities of the compounds were evaluated by the tests performed on isolated rat ileum and were compared with atropine sulfate. 1-(Diphenylamino)-1-oxopropan-2-yl 4-methylpiperazine dithiocarbamate 18 and 1-(α-naphthylamino)-1-oxopropan- 2-yl 4-methylpiperidine dithiocarbamate 25 were found to show the best activity.