Synthesis and biological activities of some thiazolidin-4-ones

In this study, fifteen 2,3-disubstituted-4-thiazolidinone derivatives were synthesized by the reaction of Schiff bases and α-mercaptoacetic acid. The structures of the compounds were elucidated by IR, ¹H-NMR, ¹³C-NMR, mass spectral data and elementary analysis. The antihistaminic and anticholinergic activities of the compounds were determined by tests performed on isolated guinea pig trachea in comparison with aminophylline (CAS 317-34-0). Compound 15 (3-(3-(2-methyl-piperidine-1-yl) propyl]-2-(4-methylphenyl) thiazolidin-4-one hydrochloride) showed the highest inhibition (53%).