Subcutaneous polymeric matrix system poly(HEMA-BGA) for controlled release of an anticancer drug (5-fluorouracil). I. Synthesis and structure

The present study was an attempt to design a new polymer-drug composite system for local chemotherapy. Poly(hydroxyethylmethacrylate-bisglycolacrylate) carriers containing an anticancer drug, 5-fluorouracil, were prepared by low temperature radiation polymerization technique. By changing the relative amounts and the types of ingredients, drug loading and radiation dosage, polymer-drug composites with different structural properties were obtained. This paper presents the preparation procedure and analyses some of the structural properties of these novel composites.