Studies on the synthesis and antidepressant activity of some new oxime- ether derivatives

In this study, seven new 2-methyl-3-carbmethoxy-4-(3-nitrophenyl)- 1,4,5,6,7,8-hexahydroquinoline-5-one-O-(2-(N-substituted amino)ethyl)oxime derivatives have been synthesized by reacting hexahydroquinoline structure which contains ketone group with corresponding 2-amino-2-oxyethyl-N- substituted amines. Their chemical structures have been proved by IR, ¹H- NMR, Mass spectra and elementary analysis. Their antidepressant activities were investigated by 'Porsolt Behavioral Despair Test'. All the compounds were active when compared with controls. However, 2-methyl-3-carbmethoxy-4- (3-nitrophenyl)-1,4,5,6,7,8-hexahydroquinoline-5-one-O-(2-(N,N- diethylamino)ethyl)oxime showed higher inhibition of immobility.