Siyatik-femoral sinir bloǧu ile spinai anestezinin, turnikeye baǧli gelişen iskemi-reperfüzyon (I/R) hasari uzerindeki etkileri

Aim: This study was planned to investigate the effects of sciatic-femoral-nerve-block and spinal-anaesthesia on I/R injury under the tourniquet. Material and Methods: Thirty-one patients undergoing to knee arthroscopy; ASA I - II and 18-60 year-old were included and organized randomly into two groups. Femoral-sciatic-nerve-blocks was performed under guidance of ultrasonography and a nerve stimulator in patients of Group I (n=15). For the femoral-sciatic-nerve-blocks, 20 mL of 0.5 % bupivacaine and 20 mL of 2 % prilocaine (40 mL totally) were mixtured. Twenty ml of it was injected into each of the femoral and sciatic nerves. Spinal-anaesthesia was performed at L _4-5 level by using 12.5 mg of 0.5 % bupivacaine in patients of group II (n=16). After then the tourniquet was inflated to 300 mmHg for each patient. Blood samples were taken at different times; before the anaesthesia (T ₀), before the beginning of the surgery and inflation of tourniquet (T₁), 30 minutes after tourniquet (T₂), and 10 minutes after deflation of tourniquet (T₃) and lipid peroxidase (LPO) and total antioxidant capacity (AOK) levels were analyzed. Results: There were no significant differences in the levels of LPO and AOK between the groups. Within group comparisons, levels of AOK were found to decreased significantly at all times than T₀ in both groups (p<0.008). The levels of LPO showed no differences in all times of group II however there were significant differences in group I between T₀-T₂, T₀-T ₃, T₁-T₂, T₁-T₃ (p<0.008). Conclusion: The oxidative stress and antioxidant potentials after I/R injury were found to be similar at both of the anaesthesia techniques.