Investigation of myorelaxant activity of 9-aryl-3,4,6,7-tetrahydroacridine- 1,8-(2H,5H,9H,10H)-diones in isolated rabbit gastric fundus

In this study, twelve compounds having 9-aryl- 3,4,6,7-tetrahydroacridine- 1,8-(2H,5H,9H,10H)-dione structure were synthesized by reaction of 5-methyl-1,3-cyclohexanedione, the appropriate aromatic aldehydes, and ammonium acetate in methanol. The structures of the compounds were elucidated by infrared, ¹H- and ¹³Cnuclear magnetic resonance spectroscopy (-NMR), mass spectroscopy, and elemental analysis. The maximum relaxant effects (E _max) and pD2 values of the compounds 3a-l and pinacidil were tested on isolated strips of rabbit gastric fundus smooth muscle.