In vitro activities of antibiotics alone and in combination against Brucella melitensis at neutral and acidic pHs

Murat Akova; Deniz Gür; David M. Livermore; Tanil Kocagöz; H. Erdal Akalin

doi:10.1128/aac.43.5.1298

In vitro activities of antibiotics alone and in combination against Brucella melitensis at neutral and acidic pHs

Murat Akova
, Deniz Gür
, David M. Livermore
, Tanil Kocagöz
, H. Erdal Akalin

Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı

Hacettepe University
UK Health Security Agency
Pfizer

Araştırma sonucu: Dergiye katkı › Makale › bilirkişi

77 Alıntılar (Scopus)

Özet

Brucellae survive acidic pHs in phagolysosomes. Azithromycin, streptomycin, and quinolones were active against Brucella melitensis at pit 7.0 but not at pH 5.0; rifampin and doxycycline retained activity at pH 5.0. Regardless of pH, azithromycin-rifampin and ofloxacin-rifampin showed less synergy than established streptomycin-doxycycline and rifampin-doxycycline combinations.

Orijinal dil	İngilizce
Sayfa (başlangıç-bitiş)	1298-1300
Sayfa sayısı	3
Dergi	Antimicrobial Agents and Chemotherapy
Hacim	43
Basın numarası	5
DOI'lar	https://doi.org/10.1128/aac.43.5.1298
Yayın durumu	Yayınlandı - May 1999

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10.1128/aac.43.5.1298

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title = "In vitro activities of antibiotics alone and in combination against Brucella melitensis at neutral and acidic pHs",

abstract = "Brucellae survive acidic pHs in phagolysosomes. Azithromycin, streptomycin, and quinolones were active against Brucella melitensis at pit 7.0 but not at pH 5.0; rifampin and doxycycline retained activity at pH 5.0. Regardless of pH, azithromycin-rifampin and ofloxacin-rifampin showed less synergy than established streptomycin-doxycycline and rifampin-doxycycline combinations.",

author = "Murat Akova and Deniz G{\"u}r and Livermore, \{David M.\} and Tanil Kocag{\"o}z and Akalin, \{H. Erdal\}",

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T1 - In vitro activities of antibiotics alone and in combination against Brucella melitensis at neutral and acidic pHs

AU - Akova, Murat

AU - Gür, Deniz

AU - Livermore, David M.

AU - Kocagöz, Tanil

AU - Akalin, H. Erdal

PY - 1999/5

Y1 - 1999/5

N2 - Brucellae survive acidic pHs in phagolysosomes. Azithromycin, streptomycin, and quinolones were active against Brucella melitensis at pit 7.0 but not at pH 5.0; rifampin and doxycycline retained activity at pH 5.0. Regardless of pH, azithromycin-rifampin and ofloxacin-rifampin showed less synergy than established streptomycin-doxycycline and rifampin-doxycycline combinations.

AB - Brucellae survive acidic pHs in phagolysosomes. Azithromycin, streptomycin, and quinolones were active against Brucella melitensis at pit 7.0 but not at pH 5.0; rifampin and doxycycline retained activity at pH 5.0. Regardless of pH, azithromycin-rifampin and ofloxacin-rifampin showed less synergy than established streptomycin-doxycycline and rifampin-doxycycline combinations.

UR - https://www.scopus.com/pages/publications/0345517292

U2 - 10.1128/aac.43.5.1298

DO - 10.1128/aac.43.5.1298

M3 - Article

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AN - SCOPUS:0345517292

SN - 0066-4804

VL - 43

SP - 1298

EP - 1300

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 5

ER -

In vitro activities of antibiotics alone and in combination against Brucella melitensis at neutral and acidic pHs

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