How phytochemicals influence reproductive outcomes in women receiving assisted reproductive techniques: a systematic review

Context: Over the past few years, there has been an increasing amount of scholarly literature suggesting a connection between the nutritional status of pregnant mothers and early fetal development, as well as the long-term health consequences of their offspring. Multiple studies have documented that alterations in dietary patterns prior to conception have the potential to affect the initial stages of embryonic development. Objectives: The aim of this study was to perform a comprehensive review of the research pertaining to the correlation between phytochemicals (specifically, polyphenols, carotenoids and phytoestrogens) and assisted reproductive technology (ART). Data sources: PubMed, Scopus, Web of Science, and Clinical Trials databases were searched from January 1978 to March 2023. Study Selection: This study comprised observational, randomized controlled, and cohort studies that examined the effects of phytochemicals on ART results. The study's outcomes encompass live birth rate, clinical pregnancy, and ongoing pregnancy. Data extraction: The assessment of study quality was conducted by 2 researchers, independently, using the Quality Criteria Checklist for Primary Research. Results: A total of 13 studies were included, of which there were 5 randomized controlled studies, 1 nonrandomized controlled study, 6 prospective cohort studies, and 1 retrospective cohort study. Conclusion: This research focused on investigating the impact of phytochemicals on ART and has highlighted a dearth of articles addressing that topic. Collaboration among patients, physicians, and nutritionists is crucial for doing novel research.