Extracellular Matrix-Based Conductive Composites for Myocardial Tissue Regeneration

Gülçin Günal; Dincer Gokcen; Halil Murat Aydin

doi:10.1021/acsabm.3c00557

Extracellular Matrix-Based Conductive Composites for Myocardial Tissue Regeneration

Gülçin Günal
, Dincer Gokcen
, Halil Murat Aydin

Hacettepe University
Akdeniz University

Araştırma sonucu: Dergiye katkı › Makale › bilirkişi

1 Alıntı (Scopus)

Özet

Myocardial tissue engineering strategies such as fabrication of cardiac patches for tissue regeneration offer various solutions for the loss of function developed due to myocardial infarction. Here, we combined the hybrid structure (previously obtained and combined decellularized myocardium grafts with poly(glycerol-sebacate) polymer) with multiwalled carbon nanotubes (MWCNTs) to provide the essential characteristics for cardiac tissue regeneration. MWCNTs were doped in the cross-linked structure, and the conductivity and Young’s modulus of the composite elastomer were found as 5 × 10^-3 ± 1 × 10^-3 S/m and 374 ± 75.8 kPa, respectively. The cell-material interaction was evaluated, and composite structures supported cell adhesion and showed no cytotoxic effect.

Orijinal dil	İngilizce
Sayfa (başlangıç-bitiş)	4100-4104
Sayfa sayısı	5
Dergi	ACS Applied Bio Materials
Hacim	6
Basın numarası	10
DOI'lar	https://doi.org/10.1021/acsabm.3c00557
Yayın durumu	Yayınlandı - 16 Eki 2023

Belgeye Erişim

10.1021/acsabm.3c00557

Diger dosyalar ve linkler

Link to publication in Scopus

Bundan alıntı yap

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title = "Extracellular Matrix-Based Conductive Composites for Myocardial Tissue Regeneration",

abstract = "Myocardial tissue engineering strategies such as fabrication of cardiac patches for tissue regeneration offer various solutions for the loss of function developed due to myocardial infarction. Here, we combined the hybrid structure (previously obtained and combined decellularized myocardium grafts with poly(glycerol-sebacate) polymer) with multiwalled carbon nanotubes (MWCNTs) to provide the essential characteristics for cardiac tissue regeneration. MWCNTs were doped in the cross-linked structure, and the conductivity and Young{\textquoteright}s modulus of the composite elastomer were found as 5 × 10-3 ± 1 × 10-3 S/m and 374 ± 75.8 kPa, respectively. The cell-material interaction was evaluated, and composite structures supported cell adhesion and showed no cytotoxic effect.",

keywords = "Cardiac patch, conductive biomaterial, extracellular matrix, multiwalled carbon nanotubes, poly(glycerol-sebacate)",

author = "G{\"u}l{\c c}in G{\"u}nal and Dincer Gokcen and Aydin, \{Halil Murat\}",

note = "Publisher Copyright: {\textcopyright} 2023 American Chemical Society",

year = "2023",

month = oct,

day = "16",

doi = "10.1021/acsabm.3c00557",

language = "English",

volume = "6",

pages = "4100--4104",

journal = "ACS Applied Bio Materials",

issn = "2576-6422",

publisher = "American Chemical Society",

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T1 - Extracellular Matrix-Based Conductive Composites for Myocardial Tissue Regeneration

AU - Günal, Gülçin

AU - Gokcen, Dincer

AU - Aydin, Halil Murat

PY - 2023/10/16

Y1 - 2023/10/16

N2 - Myocardial tissue engineering strategies such as fabrication of cardiac patches for tissue regeneration offer various solutions for the loss of function developed due to myocardial infarction. Here, we combined the hybrid structure (previously obtained and combined decellularized myocardium grafts with poly(glycerol-sebacate) polymer) with multiwalled carbon nanotubes (MWCNTs) to provide the essential characteristics for cardiac tissue regeneration. MWCNTs were doped in the cross-linked structure, and the conductivity and Young’s modulus of the composite elastomer were found as 5 × 10-3 ± 1 × 10-3 S/m and 374 ± 75.8 kPa, respectively. The cell-material interaction was evaluated, and composite structures supported cell adhesion and showed no cytotoxic effect.

AB - Myocardial tissue engineering strategies such as fabrication of cardiac patches for tissue regeneration offer various solutions for the loss of function developed due to myocardial infarction. Here, we combined the hybrid structure (previously obtained and combined decellularized myocardium grafts with poly(glycerol-sebacate) polymer) with multiwalled carbon nanotubes (MWCNTs) to provide the essential characteristics for cardiac tissue regeneration. MWCNTs were doped in the cross-linked structure, and the conductivity and Young’s modulus of the composite elastomer were found as 5 × 10-3 ± 1 × 10-3 S/m and 374 ± 75.8 kPa, respectively. The cell-material interaction was evaluated, and composite structures supported cell adhesion and showed no cytotoxic effect.

KW - Cardiac patch

KW - conductive biomaterial

KW - extracellular matrix

KW - multiwalled carbon nanotubes

KW - poly(glycerol-sebacate)

UR - https://www.scopus.com/pages/publications/85175877894

U2 - 10.1021/acsabm.3c00557

DO - 10.1021/acsabm.3c00557

M3 - Article

C2 - 37782232

AN - SCOPUS:85175877894

SN - 2576-6422

VL - 6

SP - 4100

EP - 4104

JO - ACS Applied Bio Materials

JF - ACS Applied Bio Materials

IS - 10

ER -

Extracellular Matrix-Based Conductive Composites for Myocardial Tissue Regeneration

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