Yüksek ve düşük akimli desfluran anestezi̇si̇ nde kogni̇ti̇f fonksi̧yonlarin deǧerlendi̇ri̇ lmesi̇

Objective: Cognitive function consists of the level of consciousness, memory, orientation, concentration, general knowledge, intelligence, understanding and judgment. Postoperative cognitive dysfunction is a multifactor state which is characterized by disability of memory and concentration. At the recovery stage, the patient's cognitive functions returning to its original level is closely related with pharmacokinetics of the anesthetic material, anesthesia, desfluran used in low and high flow anesthesia. This study aimed at examining cognitive functions in the preoperative ve postoperative period when low and high flow of desfluran anesthesia was applied. Methods: After Institutional Ethics Committee approval, ASA I/II, 32 patients of 15-55 ages two groups. One group (Group I, n=16) had high flow and the other (Group II, n=I6) had low flow. Premedication was not applied. Anesthesia was induced with 1.5 μg kg^-1 fentanyl and 5-7 mg kg^-1 thiopental. Endotracheal intubation was performed after 0.6 mg kg^-1 rocuronium. Patients, included in Group I and in Group II were applied 4 L min-1 50 % N ₂O+O₂ and 1 L min^-1 50 % N₂O+O ₂ respectively. Patient's recovery parameters were evaluated with Modified Aldrete Score (MAS) at 5., 10., 15., 30. and 60. minutes. Cognitive functions of the patients were evaluated with Verbal Auditory Memory Test (VAMT) and Stroop Interference Test (SIT). Results: No significant result was found in the preoperative and postoperative VAMT 1, VAMT 5, VAMT 6, VAMT 7, VAMT 8 and SIT scores between Group I and Group II. No correlation was confirmed between postoperative recovery time and VAMT 1, VAMT 5, VAMT 6, VAMT 7, VAMT 8, SIT score. Conclusion: Neither of the anesthetic techniques showed differences with respect to cognitive functions. We conclude that since no relationship between postoperative recovery time and cognitive functions was found, the amount of fresh gas used in the desfluran did not affect the cognitive functions.