Wilms' tumor 1 protein expression in endometrial adenocarcinoma and endometrial intra-epithelial neoplasia

Yeliz Atik; Bilge Cetinkaya Demir; Hakan Ozan; Sema Baykara; Alp Usubutun; Fatma Yılmaz Erturk

doi:10.1111/jog.12981

Wilms' tumor 1 protein expression in endometrial adenocarcinoma and endometrial intra-epithelial neoplasia

Yeliz Atik
, Bilge Cetinkaya Demir
, Hakan Ozan
, Sema Baykara
, Alp Usubutun
, Fatma Yılmaz Erturk

Division of Medical Pathology

Bursa Cekirge Government Hospital
Uludag University
Ankara Numune Education and Research Hospital

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Aim: To investigate the expression of Wilms' tumor 1 (WT1) protein in endometrial adenocarcinoma (EC) and endometrial intra-epithelial neoplasia (EIN). Methods: WT1 protein expression was determined on immunohistochemistry in 30 EC patients and in 20 EIN patients. WT1 protein expression in proliferative (n = 7), secretory (n = 9) and atrophic endometrium (n = 9) and benign endometrial polyps (n = 28) was used as the control group. Cellular and vascular WT1 staining was scored semiquantitatively. Results: Cellular WT1 staining was 67% and vascular positivity was 73% in the EC group. In the EIN group the cellular staining was 100% and vascular staining was 85%. Although all EIN samples were positive for cellular WT1 staining, median cellular staining score was similar to that of EC (median, 2; range, 1–3; IQR, 1.75 vs 2, 0–3, 0.75, respectively). Increasing EC grade and stage were not associated with cellular or vascular WT1 staining score. Conclusion: WT1 is expressed in EIN.

Original language	English
Pages (from-to)	870-875
Number of pages	6
Journal	Journal of Obstetrics and Gynaecology Research
Volume	42
Issue number	7
DOIs	https://doi.org/10.1111/jog.12981
Publication status	Published - 1 Jul 2016

Keywords

Wilms' tumor 1 protein
endometrial adenocarcinoma
endometrial intra-epithelial neoplasia

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10.1111/jog.12981

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@article{f44aa981afe540139801a77b41a27057,

title = "Wilms' tumor 1 protein expression in endometrial adenocarcinoma and endometrial intra-epithelial neoplasia",

abstract = "Aim: To investigate the expression of Wilms' tumor 1 (WT1) protein in endometrial adenocarcinoma (EC) and endometrial intra-epithelial neoplasia (EIN). Methods: WT1 protein expression was determined on immunohistochemistry in 30 EC patients and in 20 EIN patients. WT1 protein expression in proliferative (n = 7), secretory (n = 9) and atrophic endometrium (n = 9) and benign endometrial polyps (n = 28) was used as the control group. Cellular and vascular WT1 staining was scored semiquantitatively. Results: Cellular WT1 staining was 67\% and vascular positivity was 73\% in the EC group. In the EIN group the cellular staining was 100\% and vascular staining was 85\%. Although all EIN samples were positive for cellular WT1 staining, median cellular staining score was similar to that of EC (median, 2; range, 1–3; IQR, 1.75 vs 2, 0–3, 0.75, respectively). Increasing EC grade and stage were not associated with cellular or vascular WT1 staining score. Conclusion: WT1 is expressed in EIN.",

keywords = "Wilms' tumor 1 protein, endometrial adenocarcinoma, endometrial intra-epithelial neoplasia",

author = "Yeliz Atik and \{Cetinkaya Demir\}, Bilge and Hakan Ozan and Sema Baykara and Alp Usubutun and \{Yılmaz Erturk\}, Fatma",

note = "Publisher Copyright: {\textcopyright} 2016 Japan Society of Obstetrics and Gynecology",

year = "2016",

month = jul,

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doi = "10.1111/jog.12981",

language = "English",

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TY - JOUR

T1 - Wilms' tumor 1 protein expression in endometrial adenocarcinoma and endometrial intra-epithelial neoplasia

AU - Atik, Yeliz

AU - Cetinkaya Demir, Bilge

AU - Ozan, Hakan

AU - Baykara, Sema

AU - Usubutun, Alp

AU - Yılmaz Erturk, Fatma

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Aim: To investigate the expression of Wilms' tumor 1 (WT1) protein in endometrial adenocarcinoma (EC) and endometrial intra-epithelial neoplasia (EIN). Methods: WT1 protein expression was determined on immunohistochemistry in 30 EC patients and in 20 EIN patients. WT1 protein expression in proliferative (n = 7), secretory (n = 9) and atrophic endometrium (n = 9) and benign endometrial polyps (n = 28) was used as the control group. Cellular and vascular WT1 staining was scored semiquantitatively. Results: Cellular WT1 staining was 67% and vascular positivity was 73% in the EC group. In the EIN group the cellular staining was 100% and vascular staining was 85%. Although all EIN samples were positive for cellular WT1 staining, median cellular staining score was similar to that of EC (median, 2; range, 1–3; IQR, 1.75 vs 2, 0–3, 0.75, respectively). Increasing EC grade and stage were not associated with cellular or vascular WT1 staining score. Conclusion: WT1 is expressed in EIN.

AB - Aim: To investigate the expression of Wilms' tumor 1 (WT1) protein in endometrial adenocarcinoma (EC) and endometrial intra-epithelial neoplasia (EIN). Methods: WT1 protein expression was determined on immunohistochemistry in 30 EC patients and in 20 EIN patients. WT1 protein expression in proliferative (n = 7), secretory (n = 9) and atrophic endometrium (n = 9) and benign endometrial polyps (n = 28) was used as the control group. Cellular and vascular WT1 staining was scored semiquantitatively. Results: Cellular WT1 staining was 67% and vascular positivity was 73% in the EC group. In the EIN group the cellular staining was 100% and vascular staining was 85%. Although all EIN samples were positive for cellular WT1 staining, median cellular staining score was similar to that of EC (median, 2; range, 1–3; IQR, 1.75 vs 2, 0–3, 0.75, respectively). Increasing EC grade and stage were not associated with cellular or vascular WT1 staining score. Conclusion: WT1 is expressed in EIN.

KW - Wilms' tumor 1 protein

KW - endometrial adenocarcinoma

KW - endometrial intra-epithelial neoplasia

UR - https://www.scopus.com/pages/publications/84977107141

U2 - 10.1111/jog.12981

DO - 10.1111/jog.12981

M3 - Article

C2 - 27062662

AN - SCOPUS:84977107141

SN - 1341-8076

VL - 42

SP - 870

EP - 875

JO - Journal of Obstetrics and Gynaecology Research

JF - Journal of Obstetrics and Gynaecology Research

IS - 7

ER -

Wilms' tumor 1 protein expression in endometrial adenocarcinoma and endometrial intra-epithelial neoplasia

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