Vasorelaxing properties of some phenylacridine type potassium channel openers in isolated rabbit thoracic arteries

Öcal Berkan; Bülent Saraç; Rahime Şimşek; Şahin Yildirim; Yusuf Sarioǧlu; Cihat Şafak

doi:10.1016/S0223-5234(02)01374-0

Vasorelaxing properties of some phenylacridine type potassium channel openers in isolated rabbit thoracic arteries

Öcal Berkan
, Bülent Saraç
, Rahime Şimşek
, Şahin Yildirim
, Yusuf Sarioǧlu
, Cihat Şafak

Division of Pharmaceutical Chemistry (Pharmacy)

Cumhuriyet University
Hacettepe University

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Abstract

In this study, 12 new 2,2,7,7-tetramethyl-9-aryl-2,3,4,5,6,7,9,10-octahydro-1,8-acridindione derivatives were synthesised and their effects on vascular potassium channels and mechanism of induced relaxations on phenylephrine-induced contractile responses in isolated rabbit thoracic arteries was investigated. Pinacidil was used as standard potassium channel openers in this study. Compounds 1-12 and pinacidil exerted concentration-dependent relaxation responses precontracted phenylephrine in the aortic rings with the efficacy order: 11>pinacidil>7>2>8>3>1>4>10>6>9>5>12.

Original language	English
Pages (from-to)	519-523
Number of pages	5
Journal	European Journal of Medicinal Chemistry
Volume	37
Issue number	6
DOIs	https://doi.org/10.1016/S0223-5234(02)01374-0
Publication status	Published - Jun 2002

Keywords

Acridindione
Potassium channel openers
Synthesis

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10.1016/S0223-5234(02)01374-0

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title = "Vasorelaxing properties of some phenylacridine type potassium channel openers in isolated rabbit thoracic arteries",

abstract = "In this study, 12 new 2,2,7,7-tetramethyl-9-aryl-2,3,4,5,6,7,9,10-octahydro-1,8-acridindione derivatives were synthesised and their effects on vascular potassium channels and mechanism of induced relaxations on phenylephrine-induced contractile responses in isolated rabbit thoracic arteries was investigated. Pinacidil was used as standard potassium channel openers in this study. Compounds 1-12 and pinacidil exerted concentration-dependent relaxation responses precontracted phenylephrine in the aortic rings with the efficacy order: 11>pinacidil>7>2>8>3>1>4>10>6>9>5>12.",

keywords = "Acridindione, Potassium channel openers, Synthesis",

author = "{\"O}cal Berkan and B{\"u}lent Sara{\c c} and Rahime {\c S}im{\c s}ek and {\c S}ahin Yildirim and Yusuf Sarioǧlu and Cihat {\c S}afak",

year = "2002",

month = jun,

doi = "10.1016/S0223-5234(02)01374-0",

language = "English",

volume = "37",

pages = "519--523",

journal = "European Journal of Medicinal Chemistry",

issn = "0223-5234",

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number = "6",

}

TY - JOUR

T1 - Vasorelaxing properties of some phenylacridine type potassium channel openers in isolated rabbit thoracic arteries

AU - Berkan, Öcal

AU - Saraç, Bülent

AU - Şimşek, Rahime

AU - Yildirim, Şahin

AU - Sarioǧlu, Yusuf

AU - Şafak, Cihat

PY - 2002/6

Y1 - 2002/6

N2 - In this study, 12 new 2,2,7,7-tetramethyl-9-aryl-2,3,4,5,6,7,9,10-octahydro-1,8-acridindione derivatives were synthesised and their effects on vascular potassium channels and mechanism of induced relaxations on phenylephrine-induced contractile responses in isolated rabbit thoracic arteries was investigated. Pinacidil was used as standard potassium channel openers in this study. Compounds 1-12 and pinacidil exerted concentration-dependent relaxation responses precontracted phenylephrine in the aortic rings with the efficacy order: 11>pinacidil>7>2>8>3>1>4>10>6>9>5>12.

AB - In this study, 12 new 2,2,7,7-tetramethyl-9-aryl-2,3,4,5,6,7,9,10-octahydro-1,8-acridindione derivatives were synthesised and their effects on vascular potassium channels and mechanism of induced relaxations on phenylephrine-induced contractile responses in isolated rabbit thoracic arteries was investigated. Pinacidil was used as standard potassium channel openers in this study. Compounds 1-12 and pinacidil exerted concentration-dependent relaxation responses precontracted phenylephrine in the aortic rings with the efficacy order: 11>pinacidil>7>2>8>3>1>4>10>6>9>5>12.

KW - Acridindione

KW - Potassium channel openers

KW - Synthesis

UR - https://www.scopus.com/pages/publications/0036592251

U2 - 10.1016/S0223-5234(02)01374-0

DO - 10.1016/S0223-5234(02)01374-0

M3 - Article

C2 - 12204478

AN - SCOPUS:0036592251

SN - 0223-5234

VL - 37

SP - 519

EP - 523

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

IS - 6

ER -

Vasorelaxing properties of some phenylacridine type potassium channel openers in isolated rabbit thoracic arteries

Abstract

Keywords

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