Vascular response to titanium dioxide: A study on the rat carotid artery

Murat Cavit Çehreli; Mehmet Ali Onur; Zeynep Taş; Saime Şahin

doi:10.1002/jbm.b.30042

Vascular response to titanium dioxide: A study on the rat carotid artery

Murat Cavit Çehreli
, Mehmet Ali Onur
, Zeynep Taş
, Saime Şahin

Division of General Biology

Hacettepe University

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

The purpose of this study was to explore the effects of titanium dioxide (TiO₂) on vascular smooth muscle contractility with the use of the rat carotid-artery model. TiO₂ powder was implanted on right carotid arteries of five albino rats, the left arteries of which were left intact and served as controls. Fourteen days after placement, bilateral carotid arteries were removed and contraction/relaxation of isolated vessel rings were measured for dose-dependent epinephrine and acetylcholine administrations by a force displacement transducer. The data of each tissue specimen were collected with the use of a computerized system and corresponding software at a sample rate of 1000 kHz, and were expressed as contraction force. Contraction forces of control and TiO₂-implanted vessel rings were similar (P > 0.05). TiO ₂ does not appear to have adverse effects on vascular contractility.

Original language	English
Pages (from-to)	348-353
Number of pages	6
Journal	Journal of Biomedical Materials Research - Part B Applied Biomaterials
Volume	70
Issue number	2
DOIs	https://doi.org/10.1002/jbm.b.30042
Publication status	Published - 15 Aug 2004

Keywords

Blood vessel
Titanuim dioxide
Vasoconstriction
Vasodilatation
Vessel wall tonus

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10.1002/jbm.b.30042

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title = "Vascular response to titanium dioxide: A study on the rat carotid artery",

abstract = "The purpose of this study was to explore the effects of titanium dioxide (TiO2) on vascular smooth muscle contractility with the use of the rat carotid-artery model. TiO2 powder was implanted on right carotid arteries of five albino rats, the left arteries of which were left intact and served as controls. Fourteen days after placement, bilateral carotid arteries were removed and contraction/relaxation of isolated vessel rings were measured for dose-dependent epinephrine and acetylcholine administrations by a force displacement transducer. The data of each tissue specimen were collected with the use of a computerized system and corresponding software at a sample rate of 1000 kHz, and were expressed as contraction force. Contraction forces of control and TiO2-implanted vessel rings were similar (P > 0.05). TiO 2 does not appear to have adverse effects on vascular contractility.",

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AU - Çehreli, Murat Cavit

AU - Onur, Mehmet Ali

AU - Taş, Zeynep

AU - Şahin, Saime

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AB - The purpose of this study was to explore the effects of titanium dioxide (TiO2) on vascular smooth muscle contractility with the use of the rat carotid-artery model. TiO2 powder was implanted on right carotid arteries of five albino rats, the left arteries of which were left intact and served as controls. Fourteen days after placement, bilateral carotid arteries were removed and contraction/relaxation of isolated vessel rings were measured for dose-dependent epinephrine and acetylcholine administrations by a force displacement transducer. The data of each tissue specimen were collected with the use of a computerized system and corresponding software at a sample rate of 1000 kHz, and were expressed as contraction force. Contraction forces of control and TiO2-implanted vessel rings were similar (P > 0.05). TiO 2 does not appear to have adverse effects on vascular contractility.

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KW - Vasodilatation

KW - Vessel wall tonus

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Vascular response to titanium dioxide: A study on the rat carotid artery

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Keywords

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