Abstract
The aim of the present study was to evaluate whether aluminum exposure may cause alterations of cytochrome P 4503A4 by measuring the urinary excretion of 6β-hydroxycortisol as biomarker. There is a positive correlation between urinary 6β-hydroxycortisol and aluminum excretion (p<0.05). The correlations between occupational duration, smoking habits, and age were also evaluated. The increased excretion of the biomarker suggests that this element may induce formation of cytochrome P 450 in exposed individuals.
| Original language | English |
|---|---|
| Pages (from-to) | 36-41 |
| Number of pages | 6 |
| Journal | Biological Trace Element Research |
| Volume | 120 |
| Issue number | 1-3 |
| DOIs | |
| Publication status | Published - Dec 2007 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- 6β-Hydroxycortisol
- Aluminum
- Biomarker
- Cytochrome P
- Enzyme induction
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