Triterpene saponins from cyclamen trocopteranthum

Ghezala Mihci-Gaidi; Suheyla Ozbey; Ilkay Orhan; Bilge Sener; Tomofumi Miyamoto; Jean François Mirjolet; Olivier Duchamp; Anne Claire Mitaine-Offer; Marie Aleth Lacaille-Dubois

doi:10.1055/s-0029-1240727

Triterpene saponins from cyclamen trocopteranthum

Ghezala Mihci-Gaidi
, Suheyla Ozbey
, Ilkay Orhan
, Bilge Sener
, Tomofumi Miyamoto
, Jean François Mirjolet
, Olivier Duchamp
, Anne Claire Mitaine-Offer
, Marie Aleth Lacaille-Dubois

Hacettepe University

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Two new triterpene saponins (12) together with three known saponins, deglucocyclamin I (3), cyclamin (4), and mirabilin (5), were isolated from the tubers of Cyclamen trocopteranthum. They were elucidated as 3-O-{4-O-[3- hydroxyl-3-methylglutaryl] - D-xylopyranosyl-(12) - D-glucopyranosyl-(14)-[-D- glucopyranosyl-(12)] - L-arabinopyranosyl}-16-hydroxy-13,28-epoxy-oleanan-30-al (1) and 3-O-{4-O-[3-hydroxyl-3-methylglutaryl] - D-xylopyranosyl-(12)-[-D- glucopyranosyl-(16)] - D-glucopyranosyl-(14)-[-D-glucopyranosyl-(12)] - L-arabinopyranosyl}-16-hydroxy-20,30-lactone-olean-12-ene (2). Their structures were characterized mainly by a combination of 1D- and 2DNMR techniques ( ¹H-¹H COSY, TOCSY, NOESY, HSQC, and HMBC) and mass spectroscopy. Saponins 1, 3, and 4 showed a weak cytotoxic activity when tested against HT-29 and HCT 116 tumor colon cancer cells.

Original language	English
Pages (from-to)	818-821
Number of pages	4
Journal	Planta Medica
Volume	76
Issue number	8
DOIs	https://doi.org/10.1055/s-0029-1240727
Publication status	Published - 2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cyclamen trocopteranthum
Dicrotalic acid
Primulaceae
Triterpene saponin

Access to Document

10.1055/s-0029-1240727

Cite this

@article{3f02bee367f340ff8b5853467255f821,

title = "Triterpene saponins from cyclamen trocopteranthum",

abstract = "Two new triterpene saponins (12) together with three known saponins, deglucocyclamin I (3), cyclamin (4), and mirabilin (5), were isolated from the tubers of Cyclamen trocopteranthum. They were elucidated as 3-O-\{4-O-[3- hydroxyl-3-methylglutaryl] - D-xylopyranosyl-(12) - D-glucopyranosyl-(14)-[-D- glucopyranosyl-(12)] - L-arabinopyranosyl\}-16-hydroxy-13,28-epoxy-oleanan-30-al (1) and 3-O-\{4-O-[3-hydroxyl-3-methylglutaryl] - D-xylopyranosyl-(12)-[-D- glucopyranosyl-(16)] - D-glucopyranosyl-(14)-[-D-glucopyranosyl-(12)] - L-arabinopyranosyl\}-16-hydroxy-20,30-lactone-olean-12-ene (2). Their structures were characterized mainly by a combination of 1D- and 2DNMR techniques ( 1H-1H COSY, TOCSY, NOESY, HSQC, and HMBC) and mass spectroscopy. Saponins 1, 3, and 4 showed a weak cytotoxic activity when tested against HT-29 and HCT 116 tumor colon cancer cells.",

keywords = "Cyclamen trocopteranthum, Dicrotalic acid, Primulaceae, Triterpene saponin",

author = "Ghezala Mihci-Gaidi and Suheyla Ozbey and Ilkay Orhan and Bilge Sener and Tomofumi Miyamoto and Mirjolet, \{Jean Fran{\c c}ois\} and Olivier Duchamp and Mitaine-Offer, \{Anne Claire\} and Lacaille-Dubois, \{Marie Aleth\}",

year = "2010",

doi = "10.1055/s-0029-1240727",

language = "English",

volume = "76",

pages = "818--821",

journal = "Planta Medica",

issn = "0032-0943",

publisher = "Georg Thieme Verlag",

number = "8",

}

TY - JOUR

T1 - Triterpene saponins from cyclamen trocopteranthum

AU - Mihci-Gaidi, Ghezala

AU - Ozbey, Suheyla

AU - Orhan, Ilkay

AU - Sener, Bilge

AU - Miyamoto, Tomofumi

AU - Mirjolet, Jean François

AU - Duchamp, Olivier

AU - Mitaine-Offer, Anne Claire

AU - Lacaille-Dubois, Marie Aleth

PY - 2010

Y1 - 2010

N2 - Two new triterpene saponins (12) together with three known saponins, deglucocyclamin I (3), cyclamin (4), and mirabilin (5), were isolated from the tubers of Cyclamen trocopteranthum. They were elucidated as 3-O-{4-O-[3- hydroxyl-3-methylglutaryl] - D-xylopyranosyl-(12) - D-glucopyranosyl-(14)-[-D- glucopyranosyl-(12)] - L-arabinopyranosyl}-16-hydroxy-13,28-epoxy-oleanan-30-al (1) and 3-O-{4-O-[3-hydroxyl-3-methylglutaryl] - D-xylopyranosyl-(12)-[-D- glucopyranosyl-(16)] - D-glucopyranosyl-(14)-[-D-glucopyranosyl-(12)] - L-arabinopyranosyl}-16-hydroxy-20,30-lactone-olean-12-ene (2). Their structures were characterized mainly by a combination of 1D- and 2DNMR techniques ( 1H-1H COSY, TOCSY, NOESY, HSQC, and HMBC) and mass spectroscopy. Saponins 1, 3, and 4 showed a weak cytotoxic activity when tested against HT-29 and HCT 116 tumor colon cancer cells.

AB - Two new triterpene saponins (12) together with three known saponins, deglucocyclamin I (3), cyclamin (4), and mirabilin (5), were isolated from the tubers of Cyclamen trocopteranthum. They were elucidated as 3-O-{4-O-[3- hydroxyl-3-methylglutaryl] - D-xylopyranosyl-(12) - D-glucopyranosyl-(14)-[-D- glucopyranosyl-(12)] - L-arabinopyranosyl}-16-hydroxy-13,28-epoxy-oleanan-30-al (1) and 3-O-{4-O-[3-hydroxyl-3-methylglutaryl] - D-xylopyranosyl-(12)-[-D- glucopyranosyl-(16)] - D-glucopyranosyl-(14)-[-D-glucopyranosyl-(12)] - L-arabinopyranosyl}-16-hydroxy-20,30-lactone-olean-12-ene (2). Their structures were characterized mainly by a combination of 1D- and 2DNMR techniques ( 1H-1H COSY, TOCSY, NOESY, HSQC, and HMBC) and mass spectroscopy. Saponins 1, 3, and 4 showed a weak cytotoxic activity when tested against HT-29 and HCT 116 tumor colon cancer cells.

KW - Cyclamen trocopteranthum

KW - Dicrotalic acid

KW - Primulaceae

KW - Triterpene saponin

UR - https://www.scopus.com/pages/publications/77952894218

U2 - 10.1055/s-0029-1240727

DO - 10.1055/s-0029-1240727

M3 - Article

C2 - 20072956

AN - SCOPUS:77952894218

SN - 0032-0943

VL - 76

SP - 818

EP - 821

JO - Planta Medica

JF - Planta Medica

IS - 8

ER -

Triterpene saponins from cyclamen trocopteranthum

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this