The effect of the gastrectomy on survival in patients with metastatic gastric cancer: A study of ASMO

Ozan Yazici; Nuriye Özdemir; Ayşe Ocak Duran; Serkan Menekşe; Mehmet Ali Nahit Şendur; Halit Karaca; Gamze Göksel; Erkan Arpaci; Ilhan Hacibekiroʇlu; Irem Bilgetekin; Turgut Kaçan; Metin Özkan; Sercan Aksoy; Asude Aksoy; Suna Çokmert; Mükremin Uysal; Emin Tamer Elkiran; Irfan Çiçin; Süleyman Büyükberber; Nurullah Zengin

doi:10.2217/fon.15.304

The effect of the gastrectomy on survival in patients with metastatic gastric cancer: A study of ASMO

Ozan Yazici
, Nuriye Özdemir
, Ayşe Ocak Duran
, Serkan Menekşe
, Mehmet Ali Nahit Şendur
, Halit Karaca
, Gamze Göksel
, Erkan Arpaci
, Ilhan Hacibekiroʇlu
, Irem Bilgetekin
, Turgut Kaçan
, Metin Özkan
, Sercan Aksoy
, Asude Aksoy
, Suna Çokmert
, Mükremin Uysal
, Emin Tamer Elkiran
, Irfan Çiçin
, Süleyman Büyükberber
, Nurullah Zengin

Ankara Numune Education and Research Hospital
Yildirim Beyazit Universitesi
Erciyes University
Manisa Celal Bayar University
Sakarya University
Trakya University
Gazi University
Cumhuriyet University
Inonu University
Özel Kent Hospital
Afyon Kocatepe University

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Aim: To investigate the role of surgical resection of primary tumor on overall survival (OS) in advanced gastric cancer patients at the time of diagnosis. Patients & methods: The survival rates of metastatic gastric cancer patients whose gastric primary tumor was resected at time of diagnosis were compared with metastatic gastric cancer patients whose primary tumor was nonresected. Results: The median progression-free survival and OS in operated and nonoperated group were 10 versus 6, 14 versus 9 months, respectively (p < 0.001). In multivariate analysis, gastric resection of primary tumor, Eastern Cooperative Oncology Group performance status, second-line chemotherapy had a significant effect on OS (hazard ratio [HR]: 0.52 [95% CI: 0.38-0.71], HR: 0.57 [95% CI: 0.42-0.78], HR: 1.48 [1.09-2.01]; p ≤ 0.001, p = 0.001 and p = 0.012, respectively). Conclusion: Subpopulations of patients with metastatic gastric cancer might benefit from surgical removal of primary tumor.

Original language	English
Pages (from-to)	343-354
Number of pages	12
Journal	Future Oncology
Volume	12
Issue number	3
DOIs	https://doi.org/10.2217/fon.15.304
Publication status	Published - Feb 2016
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

advanced gastric cancer
gastrectomy
resection
survival

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10.2217/fon.15.304

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Yazici, O., Özdemir, N., Duran, A. O., Menekşe, S., Nahit Şendur, M. A., Karaca, H., Göksel, G., Arpaci, E., Hacibekiroʇlu, I., Bilgetekin, I., Kaçan, T., Özkan, M., Aksoy, S., Aksoy, A., Çokmert, S., Uysal, M., Elkiran, E. T., Çiçin, I., Büyükberber, S., & Zengin, N. (2016). The effect of the gastrectomy on survival in patients with metastatic gastric cancer: A study of ASMO. Future Oncology, 12(3), 343-354. https://doi.org/10.2217/fon.15.304

@article{bcd004dd7db54511b6f6a58f26e43644,

title = "The effect of the gastrectomy on survival in patients with metastatic gastric cancer: A study of ASMO",

abstract = "Aim: To investigate the role of surgical resection of primary tumor on overall survival (OS) in advanced gastric cancer patients at the time of diagnosis. Patients \& methods: The survival rates of metastatic gastric cancer patients whose gastric primary tumor was resected at time of diagnosis were compared with metastatic gastric cancer patients whose primary tumor was nonresected. Results: The median progression-free survival and OS in operated and nonoperated group were 10 versus 6, 14 versus 9 months, respectively (p < 0.001). In multivariate analysis, gastric resection of primary tumor, Eastern Cooperative Oncology Group performance status, second-line chemotherapy had a significant effect on OS (hazard ratio [HR]: 0.52 [95\% CI: 0.38-0.71], HR: 0.57 [95\% CI: 0.42-0.78], HR: 1.48 [1.09-2.01]; p ≤ 0.001, p = 0.001 and p = 0.012, respectively). Conclusion: Subpopulations of patients with metastatic gastric cancer might benefit from surgical removal of primary tumor.",

keywords = "advanced gastric cancer, gastrectomy, resection, survival",

author = "Ozan Yazici and Nuriye {\"O}zdemir and Duran, \{Ay{\c s}e Ocak\} and Serkan Menek{\c s}e and \{Nahit {\c S}endur\}, \{Mehmet Ali\} and Halit Karaca and Gamze G{\"o}ksel and Erkan Arpaci and Ilhan Hacibekiroʇlu and Irem Bilgetekin and Turgut Ka{\c c}an and Metin {\"O}zkan and Sercan Aksoy and Asude Aksoy and Suna {\c C}okmert and M{\"u}kremin Uysal and Elkiran, \{Emin Tamer\} and Irfan {\c C}i{\c c}in and S{\"u}leyman B{\"u}y{\"u}kberber and Nurullah Zengin",

note = "Publisher Copyright: {\textcopyright} 2016 Future Medicine Ltd.",

year = "2016",

month = feb,

doi = "10.2217/fon.15.304",

language = "English",

volume = "12",

pages = "343--354",

journal = "Future Oncology",

issn = "1479-6694",

publisher = "Taylor and Francis Ltd.",

number = "3",

}

Yazici, O, Özdemir, N, Duran, AO, Menekşe, S, Nahit Şendur, MA, Karaca, H, Göksel, G, Arpaci, E, Hacibekiroʇlu, I, Bilgetekin, I, Kaçan, T, Özkan, M, Aksoy, S, Aksoy, A, Çokmert, S, Uysal, M, Elkiran, ET, Çiçin, I, Büyükberber, S & Zengin, N 2016, 'The effect of the gastrectomy on survival in patients with metastatic gastric cancer: A study of ASMO', Future Oncology, vol. 12, no. 3, pp. 343-354. https://doi.org/10.2217/fon.15.304

TY - JOUR

T1 - The effect of the gastrectomy on survival in patients with metastatic gastric cancer

T2 - A study of ASMO

AU - Yazici, Ozan

AU - Özdemir, Nuriye

AU - Duran, Ayşe Ocak

AU - Menekşe, Serkan

AU - Nahit Şendur, Mehmet Ali

AU - Karaca, Halit

AU - Göksel, Gamze

AU - Arpaci, Erkan

AU - Hacibekiroʇlu, Ilhan

AU - Bilgetekin, Irem

AU - Kaçan, Turgut

AU - Özkan, Metin

AU - Aksoy, Sercan

AU - Aksoy, Asude

AU - Çokmert, Suna

AU - Uysal, Mükremin

AU - Elkiran, Emin Tamer

AU - Çiçin, Irfan

AU - Büyükberber, Süleyman

AU - Zengin, Nurullah

PY - 2016/2

Y1 - 2016/2

N2 - Aim: To investigate the role of surgical resection of primary tumor on overall survival (OS) in advanced gastric cancer patients at the time of diagnosis. Patients & methods: The survival rates of metastatic gastric cancer patients whose gastric primary tumor was resected at time of diagnosis were compared with metastatic gastric cancer patients whose primary tumor was nonresected. Results: The median progression-free survival and OS in operated and nonoperated group were 10 versus 6, 14 versus 9 months, respectively (p < 0.001). In multivariate analysis, gastric resection of primary tumor, Eastern Cooperative Oncology Group performance status, second-line chemotherapy had a significant effect on OS (hazard ratio [HR]: 0.52 [95% CI: 0.38-0.71], HR: 0.57 [95% CI: 0.42-0.78], HR: 1.48 [1.09-2.01]; p ≤ 0.001, p = 0.001 and p = 0.012, respectively). Conclusion: Subpopulations of patients with metastatic gastric cancer might benefit from surgical removal of primary tumor.

AB - Aim: To investigate the role of surgical resection of primary tumor on overall survival (OS) in advanced gastric cancer patients at the time of diagnosis. Patients & methods: The survival rates of metastatic gastric cancer patients whose gastric primary tumor was resected at time of diagnosis were compared with metastatic gastric cancer patients whose primary tumor was nonresected. Results: The median progression-free survival and OS in operated and nonoperated group were 10 versus 6, 14 versus 9 months, respectively (p < 0.001). In multivariate analysis, gastric resection of primary tumor, Eastern Cooperative Oncology Group performance status, second-line chemotherapy had a significant effect on OS (hazard ratio [HR]: 0.52 [95% CI: 0.38-0.71], HR: 0.57 [95% CI: 0.42-0.78], HR: 1.48 [1.09-2.01]; p ≤ 0.001, p = 0.001 and p = 0.012, respectively). Conclusion: Subpopulations of patients with metastatic gastric cancer might benefit from surgical removal of primary tumor.

KW - advanced gastric cancer

KW - gastrectomy

KW - resection

KW - survival

UR - https://www.scopus.com/pages/publications/84956466822

U2 - 10.2217/fon.15.304

DO - 10.2217/fon.15.304

M3 - Article

C2 - 26775722

AN - SCOPUS:84956466822

SN - 1479-6694

VL - 12

SP - 343

EP - 354

JO - Future Oncology

JF - Future Oncology

IS - 3

ER -

The effect of the gastrectomy on survival in patients with metastatic gastric cancer: A study of ASMO

Abstract

UN SDGs

Keywords

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