Abstract
In this study, twenty two new N,N-disubstituted dithiocarbamate derivatives were synthesized. The structures of the compounds were confirmed by IR, 1H-NMR, mass spectroscopy and elemental analysis. Anticholinergic activities of the compounds were evaluated by the tests performed on isolated rat ileum and were compared with atropine sulfate. 1-(Diphenylamino)-1-oxopropan-2-yl 4-methylpiperazine dithiocarbamate 18 and 1-(α-naphthylamino)-1-oxopropan- 2-yl 4-methylpiperidine dithiocarbamate 25 were found to show the best activity.
| Original language | English |
|---|---|
| Pages (from-to) | 19-27 |
| Number of pages | 9 |
| Journal | Fabad Journal of Pharmaceutical Sciences |
| Volume | 35 |
| Issue number | 1 |
| Publication status | Published - Mar 2010 |
Keywords
- Anticholinergic activity
- Dithiocarbamic acid esters
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