Synthesis and biological activities of some thiazolidin-4-ones

Keriman Özadali; Fügen Özkanli; Dilek Erol; Ali Evrim Doǧan; Kevser Erol

doi:10.1055/s-0031-1296772

Synthesis and biological activities of some thiazolidin-4-ones

Keriman Özadali
, Fügen Özkanli
, Dilek Erol
, Ali Evrim Doǧan
, Kevser Erol

Division of Pharmaceutical Chemistry (Pharmacy)

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

In this study, fifteen 2,3-disubstituted-4-thiazolidinone derivatives were synthesized by the reaction of Schiff bases and α-mercaptoacetic acid. The structures of the compounds were elucidated by IR, ¹H-NMR, ¹³C-NMR, mass spectral data and elementary analysis. The antihistaminic and anticholinergic activities of the compounds were determined by tests performed on isolated guinea pig trachea in comparison with aminophylline (CAS 317-34-0). Compound 15 (3-(3-(2-methyl-piperidine-1-yl) propyl]-2-(4-methylphenyl) thiazolidin-4-one hydrochloride) showed the highest inhibition (53%).

Original language	English
Pages (from-to)	678-681
Number of pages	4
Journal	Arzneimittel-Forschung/Drug Research
Volume	56
Issue number	10
DOIs	https://doi.org/10.1055/s-0031-1296772
Publication status	Published - 2006

Keywords

Antihistaminic agents
Thiazolidin-4-ones, anti-cholinergic activity, anti-histaminic activity, synthesis

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10.1055/s-0031-1296772

Cite this

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abstract = "In this study, fifteen 2,3-disubstituted-4-thiazolidinone derivatives were synthesized by the reaction of Schiff bases and α-mercaptoacetic acid. The structures of the compounds were elucidated by IR, 1H-NMR, 13C-NMR, mass spectral data and elementary analysis. The antihistaminic and anticholinergic activities of the compounds were determined by tests performed on isolated guinea pig trachea in comparison with aminophylline (CAS 317-34-0). Compound 15 (3-(3-(2-methyl-piperidine-1-yl) propyl]-2-(4-methylphenyl) thiazolidin-4-one hydrochloride) showed the highest inhibition (53\%).",

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T1 - Synthesis and biological activities of some thiazolidin-4-ones

AU - Özadali, Keriman

AU - Özkanli, Fügen

AU - Erol, Dilek

AU - Doǧan, Ali Evrim

AU - Erol, Kevser

PY - 2006

Y1 - 2006

N2 - In this study, fifteen 2,3-disubstituted-4-thiazolidinone derivatives were synthesized by the reaction of Schiff bases and α-mercaptoacetic acid. The structures of the compounds were elucidated by IR, 1H-NMR, 13C-NMR, mass spectral data and elementary analysis. The antihistaminic and anticholinergic activities of the compounds were determined by tests performed on isolated guinea pig trachea in comparison with aminophylline (CAS 317-34-0). Compound 15 (3-(3-(2-methyl-piperidine-1-yl) propyl]-2-(4-methylphenyl) thiazolidin-4-one hydrochloride) showed the highest inhibition (53%).

AB - In this study, fifteen 2,3-disubstituted-4-thiazolidinone derivatives were synthesized by the reaction of Schiff bases and α-mercaptoacetic acid. The structures of the compounds were elucidated by IR, 1H-NMR, 13C-NMR, mass spectral data and elementary analysis. The antihistaminic and anticholinergic activities of the compounds were determined by tests performed on isolated guinea pig trachea in comparison with aminophylline (CAS 317-34-0). Compound 15 (3-(3-(2-methyl-piperidine-1-yl) propyl]-2-(4-methylphenyl) thiazolidin-4-one hydrochloride) showed the highest inhibition (53%).

KW - Antihistaminic agents

KW - Thiazolidin-4-ones, anti-cholinergic activity, anti-histaminic activity, synthesis

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JO - Arzneimittel-Forschung/Drug Research

JF - Arzneimittel-Forschung/Drug Research

IS - 10

ER -

Synthesis and biological activities of some thiazolidin-4-ones

Abstract

Keywords

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