Synthesis and antimicrobial activity of thiazolinomethyl-2(3H)-benzoxazolone derivatives (I)

DD D. Erol; MD D. Aytemir; N. Yuluǧ

doi:10.1016/0223-5234(96)88264-X

Synthesis and antimicrobial activity of thiazolinomethyl-2(3H)-benzoxazolone derivatives (I)

DD D. Erol
, MD D. Aytemir
, N. Yuluǧ

Division of Pharmaceutical Chemistry (Pharmacy)

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

A number of thiazolinoalkyl-2(3H)-benzoxazolones have been synthesized by using cyano derivatives of 6-acyl2 (3H)-benzoxazolones with cysteamine HCl. Their antibacterial and antifungal activities have been evaluated. The chemical structures have been proved by means of their IR, ¹H-NMR and mass spectroscopic data and by elemental analysis. The antimicrobial activity of compounds was investigated by tube dilution and disk techniques using bacteria (Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Streptococcus faecalis RSKK 10541) and yeast-like fungi (Candida parapsilosis, C albicans, C pseudotropicalis, C stellatoidea). Inhibitory effects were observed for many compounds against C albicans eg, compounds 3b and 3c MIC = 25 μg/ml, C pseudotropicalis, eg, compound 3b MIC = 12.5 βg/ml, and P aeruginosa and S faecalis, eg, compound 3c, MIC = 25 μg/ml.

Original language	English
Pages (from-to)	521-524
Number of pages	4
Journal	European Journal of Medicinal Chemistry
Volume	30
Issue number	6
DOIs	https://doi.org/10.1016/0223-5234(96)88264-X
Publication status	Published - 1995

Keywords

antibacterial agent
antifungal agent
thiazolinomethyl-2(3H)-benzoxazolone derivative

Access to Document

10.1016/0223-5234(96)88264-X

Cite this

@article{39561207d119474a91d3c34eaa0f28e3,

title = "Synthesis and antimicrobial activity of thiazolinomethyl-2(3H)-benzoxazolone derivatives (I)",

abstract = "A number of thiazolinoalkyl-2(3H)-benzoxazolones have been synthesized by using cyano derivatives of 6-acyl2 (3H)-benzoxazolones with cysteamine HCl. Their antibacterial and antifungal activities have been evaluated. The chemical structures have been proved by means of their IR, 1H-NMR and mass spectroscopic data and by elemental analysis. The antimicrobial activity of compounds was investigated by tube dilution and disk techniques using bacteria (Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Streptococcus faecalis RSKK 10541) and yeast-like fungi (Candida parapsilosis, C albicans, C pseudotropicalis, C stellatoidea). Inhibitory effects were observed for many compounds against C albicans eg, compounds 3b and 3c MIC = 25 μg/ml, C pseudotropicalis, eg, compound 3b MIC = 12.5 βg/ml, and P aeruginosa and S faecalis, eg, compound 3c, MIC = 25 μg/ml.",

keywords = "antibacterial agent, antifungal agent, thiazolinomethyl-2(3H)-benzoxazolone derivative",

author = "Erol, \{DD D.\} and Aytemir, \{MD D.\} and N. Yuluǧ",

year = "1995",

doi = "10.1016/0223-5234(96)88264-X",

language = "English",

volume = "30",

pages = "521--524",

journal = "European Journal of Medicinal Chemistry",

issn = "0223-5234",

publisher = "Elsevier Masson s.r.l.",

number = "6",

}

TY - JOUR

T1 - Synthesis and antimicrobial activity of thiazolinomethyl-2(3H)-benzoxazolone derivatives (I)

AU - Erol, DD D.

AU - Aytemir, MD D.

AU - Yuluǧ, N.

PY - 1995

Y1 - 1995

N2 - A number of thiazolinoalkyl-2(3H)-benzoxazolones have been synthesized by using cyano derivatives of 6-acyl2 (3H)-benzoxazolones with cysteamine HCl. Their antibacterial and antifungal activities have been evaluated. The chemical structures have been proved by means of their IR, 1H-NMR and mass spectroscopic data and by elemental analysis. The antimicrobial activity of compounds was investigated by tube dilution and disk techniques using bacteria (Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Streptococcus faecalis RSKK 10541) and yeast-like fungi (Candida parapsilosis, C albicans, C pseudotropicalis, C stellatoidea). Inhibitory effects were observed for many compounds against C albicans eg, compounds 3b and 3c MIC = 25 μg/ml, C pseudotropicalis, eg, compound 3b MIC = 12.5 βg/ml, and P aeruginosa and S faecalis, eg, compound 3c, MIC = 25 μg/ml.

AB - A number of thiazolinoalkyl-2(3H)-benzoxazolones have been synthesized by using cyano derivatives of 6-acyl2 (3H)-benzoxazolones with cysteamine HCl. Their antibacterial and antifungal activities have been evaluated. The chemical structures have been proved by means of their IR, 1H-NMR and mass spectroscopic data and by elemental analysis. The antimicrobial activity of compounds was investigated by tube dilution and disk techniques using bacteria (Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Streptococcus faecalis RSKK 10541) and yeast-like fungi (Candida parapsilosis, C albicans, C pseudotropicalis, C stellatoidea). Inhibitory effects were observed for many compounds against C albicans eg, compounds 3b and 3c MIC = 25 μg/ml, C pseudotropicalis, eg, compound 3b MIC = 12.5 βg/ml, and P aeruginosa and S faecalis, eg, compound 3c, MIC = 25 μg/ml.

KW - antibacterial agent

KW - antifungal agent

KW - thiazolinomethyl-2(3H)-benzoxazolone derivative

UR - https://www.scopus.com/pages/publications/0029032682

UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=performanshacettepe&SrcAuth=WosAPI&KeyUT=WOS:A1995RF74500009&DestLinkType=FullRecord&DestApp=WOS_CPL

U2 - 10.1016/0223-5234(96)88264-X

DO - 10.1016/0223-5234(96)88264-X

M3 - Article

AN - SCOPUS:0029032682

SN - 0223-5234

VL - 30

SP - 521

EP - 524

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

IS - 6

ER -

Synthesis and antimicrobial activity of thiazolinomethyl-2(3H)-benzoxazolone derivatives (I)

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this