89Zr as a promising radionuclide and it’s applications for effective cancer imaging

E. Tugce Sarcan; Mine Silindir-Gunay; A. Yekta Ozer; Neil Hartman

doi:10.1007/s10967-021-07928-0

⁸⁹Zr as a promising radionuclide and it’s applications for effective cancer imaging

E. Tugce Sarcan
, Mine Silindir-Gunay
, A. Yekta Ozer
, Neil Hartman

Division of Radiopharmacy (Pharmacy)

Hacettepe University
Swansea Bay University Health Board

Research output: Contribution to journal › Review article › peer-review

15 Citations (Scopus)

Abstract

Molecular imaging using PET plays an important role for the diagnosis of different diseases. Immuno-PET combines the utilization of PET radionuclides and antibodies/proteins/peptides, presenting a popular method for imaging of different diseases, including cancer. ⁸⁹Zr is an attractive radiometal for immuno-PET but far from ideal due to its high radiation dose for the patients. However, its long half-life is sometimes advantageous and suitable for labelling antibodies, proteins and other biomolecules. This review compiles opportunities and applications for using ⁸⁹Zr in preclinical and clinical practice. It contains either results from for its production, preclinical and clinical studies.

Original language	English
Pages (from-to)	15-28
Number of pages	14
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume	330
Issue number	1
DOIs	https://doi.org/10.1007/s10967-021-07928-0
Publication status	Published - Oct 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Zr
Zr radiolabelling
Zr-gold NPs
Zr-mAb
immuno-PET

Access to Document

10.1007/s10967-021-07928-0

Cite this

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AU - Silindir-Gunay, Mine

AU - Ozer, A. Yekta

AU - Hartman, Neil

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