Subcutaneous polymeric matrix system poly(HEMA-BGA) for controlled release of an anticancer drug (5-fluorouracil). I. Synthesis and structure

Adil Denizli; Menemşe Kiremitçi; Erhan Pişkin

doi:10.1016/0142-9612(88)90094-4

Subcutaneous polymeric matrix system poly(HEMA-BGA) for controlled release of an anticancer drug (5-fluorouracil). I. Synthesis and structure

Adil Denizli
, Menemşe Kiremitçi
, Erhan Pişkin

Division of Biochemistry

Hacettepe University

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

The present study was an attempt to design a new polymer-drug composite system for local chemotherapy. Poly(hydroxyethylmethacrylate-bisglycolacrylate) carriers containing an anticancer drug, 5-fluorouracil, were prepared by low temperature radiation polymerization technique. By changing the relative amounts and the types of ingredients, drug loading and radiation dosage, polymer-drug composites with different structural properties were obtained. This paper presents the preparation procedure and analyses some of the structural properties of these novel composites.

Original language	English
Pages (from-to)	257-262
Number of pages	6
Journal	Biomaterials
Volume	9
Issue number	3
DOIs	https://doi.org/10.1016/0142-9612(88)90094-4
Publication status	Published - May 1988

Keywords

Controlled release
P(HEMA-BGA)
fluorouracil
subcutaneous

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10.1016/0142-9612(88)90094-4

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AU - Pişkin, Erhan

PY - 1988/5

Y1 - 1988/5

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AB - The present study was an attempt to design a new polymer-drug composite system for local chemotherapy. Poly(hydroxyethylmethacrylate-bisglycolacrylate) carriers containing an anticancer drug, 5-fluorouracil, were prepared by low temperature radiation polymerization technique. By changing the relative amounts and the types of ingredients, drug loading and radiation dosage, polymer-drug composites with different structural properties were obtained. This paper presents the preparation procedure and analyses some of the structural properties of these novel composites.

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KW - P(HEMA-BGA)

KW - fluorouracil

KW - subcutaneous

UR - https://www.scopus.com/pages/publications/0023899342

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ER -

Subcutaneous polymeric matrix system poly(HEMA-BGA) for controlled release of an anticancer drug (5-fluorouracil). I. Synthesis and structure

Abstract

Keywords

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