Secondary association of <i>PDLIM5</i> with paranoid schizophrenia in Emirati patients

Hamdy Moselhy; Valsamma Eapen; Nadia A. Akawi; Ali Younis; Badr Salih; Aws R. Othman; Said Yousef; Raymond A. Clarke; Bassam R. Ali

doi:10.1016/j.mgene.2015.07.002

Secondary association of <i>PDLIM5</i> with paranoid schizophrenia in Emirati patients

Hamdy Moselhy
, Valsamma Eapen
, Nadia A. Akawi
, Ali Younis
, Badr Salih
, Aws R. Othman
, Said Yousef
, Raymond A. Clarke
, Bassam R. Ali

Department of Chemistry

United Arab Emirates University
University of New South Wales Sydney
Western Sydney University

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Schizophrenia is a clinically and genetically heterogeneous disorder of unknown etiology. PDLIM5 variants have been linked to schizophrenia and other related neuropsychiatric disorders and upregulated in the brain of schizophrenia patients suggesting a possible pathogenic role in disease progression. The aim of this study is to examine the potential association of schizophrenia in Emirati patients with previously reported variants in PDLIM5, PICK1, NRG3 or DISC1 genes. Consequently, we found a secondary association between PDLIM5 variants and the paranoid subtype of schizophrenia in Emirati Arabs suggesting that PDLIM5 may represent a determinate/marker for schizophrenia subtype specification. However, no associations were found with variants in PICK1, NRG3 or DISC1 genes. (C) 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license

Original language	English
Pages (from-to)	135-139
Number of pages	5
Journal	Human Gene
Volume	5
DOIs	https://doi.org/10.1016/j.mgene.2015.07.002
Publication status	Published - Sept 2015

Keywords

Disc1
Genetics
Nrg3
Pdlim5
Pick1
Schizophrenia

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10.1016/j.mgene.2015.07.002

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title = "Secondary association of PDLIM5 with paranoid schizophrenia in Emirati patients",

abstract = "Schizophrenia is a clinically and genetically heterogeneous disorder of unknown etiology. PDLIM5 variants have been linked to schizophrenia and other related neuropsychiatric disorders and upregulated in the brain of schizophrenia patients suggesting a possible pathogenic role in disease progression. The aim of this study is to examine the potential association of schizophrenia in Emirati patients with previously reported variants in PDLIM5, PICK1, NRG3 or DISC1 genes. Consequently, we found a secondary association between PDLIM5 variants and the paranoid subtype of schizophrenia in Emirati Arabs suggesting that PDLIM5 may represent a determinate/marker for schizophrenia subtype specification. However, no associations were found with variants in PICK1, NRG3 or DISC1 genes. (C) 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license",

keywords = "Disc1, Genetics, Nrg3, Pdlim5, Pick1, Schizophrenia",

author = "Hamdy Moselhy and Valsamma Eapen and Akawi, \{Nadia A.\} and Ali Younis and Badr Salih and Othman, \{Aws R.\} and Said Yousef and Clarke, \{Raymond A.\} and Ali, \{Bassam R.\}",

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AU - Moselhy, Hamdy

AU - Eapen, Valsamma

AU - Akawi, Nadia A.

AU - Younis, Ali

AU - Salih, Badr

AU - Othman, Aws R.

AU - Yousef, Said

AU - Clarke, Raymond A.

AU - Ali, Bassam R.

PY - 2015/9

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N2 - Schizophrenia is a clinically and genetically heterogeneous disorder of unknown etiology. PDLIM5 variants have been linked to schizophrenia and other related neuropsychiatric disorders and upregulated in the brain of schizophrenia patients suggesting a possible pathogenic role in disease progression. The aim of this study is to examine the potential association of schizophrenia in Emirati patients with previously reported variants in PDLIM5, PICK1, NRG3 or DISC1 genes. Consequently, we found a secondary association between PDLIM5 variants and the paranoid subtype of schizophrenia in Emirati Arabs suggesting that PDLIM5 may represent a determinate/marker for schizophrenia subtype specification. However, no associations were found with variants in PICK1, NRG3 or DISC1 genes. (C) 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license

AB - Schizophrenia is a clinically and genetically heterogeneous disorder of unknown etiology. PDLIM5 variants have been linked to schizophrenia and other related neuropsychiatric disorders and upregulated in the brain of schizophrenia patients suggesting a possible pathogenic role in disease progression. The aim of this study is to examine the potential association of schizophrenia in Emirati patients with previously reported variants in PDLIM5, PICK1, NRG3 or DISC1 genes. Consequently, we found a secondary association between PDLIM5 variants and the paranoid subtype of schizophrenia in Emirati Arabs suggesting that PDLIM5 may represent a determinate/marker for schizophrenia subtype specification. However, no associations were found with variants in PICK1, NRG3 or DISC1 genes. (C) 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license

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KW - Pick1

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JO - Human Gene

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Secondary association of <i>PDLIM5</i> with paranoid schizophrenia in Emirati patients

Abstract

Keywords

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