Search for antifungal compounds from some Verbascum species growing in Turkey

I. Irem Tatli; Zeliha Ş Akdemir; Erdal Bedir; Ikhlas A. Khan

Search for antifungal compounds from some Verbascum species growing in Turkey

I. Irem Tatli
, Zeliha Ş Akdemir
, Erdal Bedir
, Ikhlas A. Khan

Division of Pharmaceutical Botany

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Turkish medicinal plants provide a rich source of biologically-active natural products. With the use of simple bioassays, it is possible to evaluate the bioactivity of the natural compounds. Antifungal screening of 16 compounds in a matrix format from two Verbascum species growing in Turkey was conducted directly on thin-layer chromatographic (TLC) plates sprayed with a spore suspension. Compounds possessing strong antifungal activity produced a clear zone of inhibition bounded by a sharp margin regardless of the size of the inhibitory zone. Ilwensisaponin A and C from Verbascum pterocalycinum var. mutense Hub.-Mor. were found to be active. Bioautographic assay indicated that the saponins appeared to be the most effective against Colletotrichum acutatum, C. fragariae and C. gloeosporioides.

Original language	English
Pages (from-to)	137-140
Number of pages	4
Journal	Fabad Journal of Pharmaceutical Sciences
Volume	28
Issue number	3
Publication status	Published - Sept 2004

Keywords

Antifungal Activity
Bioactive Compounds
Ilwensisaponin A
Ilwensisaponin C
Medicinal plants
Saponins
Scrophulariaceae
Verbascum lasianthum
Verbascum pterocalycinum var. mutense

Cite this

@article{3fcca299c9f9432ba2d67c8a4f6b5e80,

title = "Search for antifungal compounds from some Verbascum species growing in Turkey",

abstract = "Turkish medicinal plants provide a rich source of biologically-active natural products. With the use of simple bioassays, it is possible to evaluate the bioactivity of the natural compounds. Antifungal screening of 16 compounds in a matrix format from two Verbascum species growing in Turkey was conducted directly on thin-layer chromatographic (TLC) plates sprayed with a spore suspension. Compounds possessing strong antifungal activity produced a clear zone of inhibition bounded by a sharp margin regardless of the size of the inhibitory zone. Ilwensisaponin A and C from Verbascum pterocalycinum var. mutense Hub.-Mor. were found to be active. Bioautographic assay indicated that the saponins appeared to be the most effective against Colletotrichum acutatum, C. fragariae and C. gloeosporioides.",

keywords = "Antifungal Activity, Bioactive Compounds, Ilwensisaponin A, Ilwensisaponin C, Medicinal plants, Saponins, Scrophulariaceae, Verbascum lasianthum, Verbascum pterocalycinum var. mutense",

author = "Tatli, \{I. Irem\} and Akdemir, \{Zeliha {\c S}\} and Erdal Bedir and Khan, \{Ikhlas A.\}",

year = "2004",

month = sep,

language = "English",

volume = "28",

pages = "137--140",

journal = "Fabad Journal of Pharmaceutical Sciences",

issn = "1300-4182",

publisher = "Society of Pharmaceutical Sciences of Ankara (FABAD)",

number = "3",

}

TY - JOUR

T1 - Search for antifungal compounds from some Verbascum species growing in Turkey

AU - Tatli, I. Irem

AU - Akdemir, Zeliha Ş

AU - Bedir, Erdal

AU - Khan, Ikhlas A.

PY - 2004/9

Y1 - 2004/9

N2 - Turkish medicinal plants provide a rich source of biologically-active natural products. With the use of simple bioassays, it is possible to evaluate the bioactivity of the natural compounds. Antifungal screening of 16 compounds in a matrix format from two Verbascum species growing in Turkey was conducted directly on thin-layer chromatographic (TLC) plates sprayed with a spore suspension. Compounds possessing strong antifungal activity produced a clear zone of inhibition bounded by a sharp margin regardless of the size of the inhibitory zone. Ilwensisaponin A and C from Verbascum pterocalycinum var. mutense Hub.-Mor. were found to be active. Bioautographic assay indicated that the saponins appeared to be the most effective against Colletotrichum acutatum, C. fragariae and C. gloeosporioides.

AB - Turkish medicinal plants provide a rich source of biologically-active natural products. With the use of simple bioassays, it is possible to evaluate the bioactivity of the natural compounds. Antifungal screening of 16 compounds in a matrix format from two Verbascum species growing in Turkey was conducted directly on thin-layer chromatographic (TLC) plates sprayed with a spore suspension. Compounds possessing strong antifungal activity produced a clear zone of inhibition bounded by a sharp margin regardless of the size of the inhibitory zone. Ilwensisaponin A and C from Verbascum pterocalycinum var. mutense Hub.-Mor. were found to be active. Bioautographic assay indicated that the saponins appeared to be the most effective against Colletotrichum acutatum, C. fragariae and C. gloeosporioides.

KW - Antifungal Activity

KW - Bioactive Compounds

KW - Ilwensisaponin A

KW - Ilwensisaponin C

KW - Medicinal plants

KW - Saponins

KW - Scrophulariaceae

KW - Verbascum lasianthum

KW - Verbascum pterocalycinum var. mutense

UR - https://www.scopus.com/pages/publications/8144220214

M3 - Article

AN - SCOPUS:8144220214

SN - 1300-4182

VL - 28

SP - 137

EP - 140

JO - Fabad Journal of Pharmaceutical Sciences

JF - Fabad Journal of Pharmaceutical Sciences

IS - 3

ER -

Search for antifungal compounds from some Verbascum species growing in Turkey

Abstract

Keywords

Other files and links

Fingerprint

Cite this