TY - JOUR
T1 - Recovery course of foveal microstructure in the nonsurgical resolution of full-thickness macular hole
AU - on behalf of Collaborators of the Nonsurgical Resolution of Macular Hole Study Group
AU - Mansour, Hana A.
AU - Uwaydat, Sami H.
AU - Parodi, Maurizio
AU - Jürgens, Ignasi
AU - Smiddy, William
AU - Ellabban, Abdallah A.
AU - Schwartz, Stephen G.
AU - Foster, Robert E.
AU - Ascaso, Javier
AU - Leoz, Marta Suarez
AU - Belotto, Silvana
AU - Mateo, Javier
AU - Olivier-Pascual, Nuria
AU - Lima, Luiz H.
AU - Navea, Amparo
AU - Neila, Elena Maria Rodríguez
AU - Castillo, Rosa Arroyo
AU - Alaman, Angel Salinas
AU - Mansour, Ahmad M.
AU - Uwaydat, Sami H.
AU - Ellabban, Abdallah A.
AU - Foster, Robert E.
AU - Lima, Luiz H.
AU - López-Guajardo, Lorenzo
AU - Kadayifcilar, Sibel
AU - Wu, Lihteh
AU - Figueroa, Marta
AU - Alsakran, Wael A.
AU - Assi, Alex
AU - Casella, Antonio Marcelo
AU - Saatci, Osman
AU - Esteban, Olivia
AU - Larripa, Sofia Fernandez
AU - Rey, Amanda
AU - Pera, Patricia
AU - Bruix, Lluís
AU - Garcia, Eduardo Pérez Salvador
AU - Lara, Javier
AU - Tripathy, Koushik
AU - Ravani, Raghav
AU - Velis, Girish
AU - Agarwal, Komal
AU - Govindahari, Vishal
AU - Sinawat, Suthasinee
AU - El Bakkali, Ismael Bakkali
AU - Hrisomalos, Frank N.
AU - Chhablani, Jay
AU - Arevalo, J. Fernando
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2022/10/1
Y1 - 2022/10/1
N2 - Purpose: To analyze the recovery course of foveal microstructures in eyes with nonsurgical healing of full-thickness macular hole (FTMH). Methods: By serial OCT scans, the temporal healing sequences were analyzed in ocular trauma, vitreomacular traction (VMT), cystoid macular edema (CME), and the remaining group. We evaluated correlations between the final best-corrected spectacle visual acuity and reconstruction time of external limiting membrane (ELM), and inner segment/outer segment (IS/OS). Results: The healing (mean±standard deviation in months) most involved fusion at the level of the outer nuclear layer (ONL) (6.3±10.5) followed by restoration of ELM (9.1±13.8), and lastly, by IS/OS regeneration (13.1±19.5). In severe blunt ocular trauma, healing was fast and involved subretinal zipper glue-like reapposition with resulting outer retinal atrophy. Best spectacle-corrected visual acuity correlated with normalization of the clivus (p=0.012), faster ELM (p=0.006), and IS/OS reconstitution (p=0.024). Recurrence of FTMH occurred when the healing was halted (3 eyes) or was aberrant by lamellar hole epiretinal proliferation (LHEP) (3 eyes) or by the persistence of VMT (1 eye). Conclusion: Recovery sequences proceeded from the ONL to the deeper layers with BCVA correlating absolutely and temporally with the restoration of outer retinal layer integrity.[Figure not available: see fulltext.]
AB - Purpose: To analyze the recovery course of foveal microstructures in eyes with nonsurgical healing of full-thickness macular hole (FTMH). Methods: By serial OCT scans, the temporal healing sequences were analyzed in ocular trauma, vitreomacular traction (VMT), cystoid macular edema (CME), and the remaining group. We evaluated correlations between the final best-corrected spectacle visual acuity and reconstruction time of external limiting membrane (ELM), and inner segment/outer segment (IS/OS). Results: The healing (mean±standard deviation in months) most involved fusion at the level of the outer nuclear layer (ONL) (6.3±10.5) followed by restoration of ELM (9.1±13.8), and lastly, by IS/OS regeneration (13.1±19.5). In severe blunt ocular trauma, healing was fast and involved subretinal zipper glue-like reapposition with resulting outer retinal atrophy. Best spectacle-corrected visual acuity correlated with normalization of the clivus (p=0.012), faster ELM (p=0.006), and IS/OS reconstitution (p=0.024). Recurrence of FTMH occurred when the healing was halted (3 eyes) or was aberrant by lamellar hole epiretinal proliferation (LHEP) (3 eyes) or by the persistence of VMT (1 eye). Conclusion: Recovery sequences proceeded from the ONL to the deeper layers with BCVA correlating absolutely and temporally with the restoration of outer retinal layer integrity.[Figure not available: see fulltext.]
KW - Cystoid macular edema
KW - External limiting membrane
KW - Full-thickness macular hole
KW - Inner segment of the photoreceptor
KW - Outer nuclear layer
KW - Outer segment of the photoreceptor
KW - Spontaneous closure
KW - Traumatic macular hole
KW - Vitreomacular traction
UR - https://www.scopus.com/pages/publications/85134188609
U2 - 10.1007/s00417-022-05672-z
DO - 10.1007/s00417-022-05672-z
M3 - Article
C2 - 35467125
AN - SCOPUS:85134188609
SN - 0721-832X
VL - 260
SP - 3173
EP - 3183
JO - Graefe's Archive for Clinical and Experimental Ophthalmology
JF - Graefe's Archive for Clinical and Experimental Ophthalmology
IS - 10
ER -