PTEN expression in diffuse large B-cell lymphomas

S Önder; I Barista; A Sungur; S Ruacan; AH Üner

PTEN expression in diffuse large B-cell lymphomas

S Önder
, I Barista
, A Sungur
, S Ruacan
, AH Üner

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Diffuse large B-cell lymphomas (DLBCL) constitute the largest subgroup of non-Hodgkin lymphomas (NHL) in adults. Although the etiology of NHL is not fully understood, different genetic abnormalities, involving particularly oncogenes, were shown as a mechanism of lymphomagenesis. Mutations of tumor suppressor genes, unlike oncogenes, have been relatively less studied in DLBCL. PTEN, a tumor suppressor gene located at 10q23, has been shown to be mutated or deleted in a variety of solid tumors. In this study, loss of PTEN expression was evaluated immunohistochemically in 102 patients with DLBCL. Partial or complete loss of PTEN was detected in about one-third of the cases, leading to the conclusion that it might contribute to the lymphomagenesis in some cases.

Original language	English
Title of host publication	Proceedings Of The Xvii Meeting International Society Of Haematology (european And African Division)
Editors	W Linkesch
Publisher	Medimond S R L
Pages	125-131
Number of pages	7
ISBN (Print)	88-323-3147-0
Publication status	Published - 2003
Event	17th European and African Division Meeting of the International-Society-of-Haematology - GRAZ, Austria Duration: 7 Sept 2003 → 10 Sept 2003

Conference

Conference	17th European and African Division Meeting of the International-Society-of-Haematology
Country/Territory	Austria
City	GRAZ
Period	7/09/03 → 10/09/03

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Tumor-suppressor
3-kinase/akt pathway
Germline mutations
Pten/mmac1
Gene
Phosphatase
Breast
Cancer

Cite this

@inproceedings{3f31d10a0acd48c5b19a41b85c9c2b8f,

title = "PTEN expression in diffuse large B-cell lymphomas",

abstract = "Diffuse large B-cell lymphomas (DLBCL) constitute the largest subgroup of non-Hodgkin lymphomas (NHL) in adults. Although the etiology of NHL is not fully understood, different genetic abnormalities, involving particularly oncogenes, were shown as a mechanism of lymphomagenesis. Mutations of tumor suppressor genes, unlike oncogenes, have been relatively less studied in DLBCL. PTEN, a tumor suppressor gene located at 10q23, has been shown to be mutated or deleted in a variety of solid tumors. In this study, loss of PTEN expression was evaluated immunohistochemically in 102 patients with DLBCL. Partial or complete loss of PTEN was detected in about one-third of the cases, leading to the conclusion that it might contribute to the lymphomagenesis in some cases.",

keywords = "Tumor-suppressor, 3-kinase/akt pathway, Germline mutations, Pten/mmac1, Gene, Phosphatase, Breast, Cancer",

author = "S {\"O}nder and I Barista and A Sungur and S Ruacan and AH {\"U}ner",

year = "2003",

language = "English",

isbn = "88-323-3147-0",

pages = "125--131",

editor = "W Linkesch",

booktitle = "Proceedings Of The Xvii Meeting International Society Of Haematology (european And African Division)",

publisher = "Medimond S R L",

note = "17th European and African Division Meeting of the International-Society-of-Haematology ; Conference date: 07-09-2003 Through 10-09-2003",

}

Önder, S, Barista, I, Sungur, A, Ruacan, S & Üner, AH 2003, PTEN expression in diffuse large B-cell lymphomas. in W Linkesch (ed.), Proceedings Of The Xvii Meeting International Society Of Haematology (european And African Division). Medimond S R L, pp. 125-131, 17th European and African Division Meeting of the International-Society-of-Haematology, GRAZ, Austria, 7/09/03.

TY - GEN

T1 - PTEN expression in diffuse large B-cell lymphomas

AU - Önder, S

AU - Barista, I

AU - Sungur, A

AU - Ruacan, S

AU - Üner, AH

PY - 2003

Y1 - 2003

N2 - Diffuse large B-cell lymphomas (DLBCL) constitute the largest subgroup of non-Hodgkin lymphomas (NHL) in adults. Although the etiology of NHL is not fully understood, different genetic abnormalities, involving particularly oncogenes, were shown as a mechanism of lymphomagenesis. Mutations of tumor suppressor genes, unlike oncogenes, have been relatively less studied in DLBCL. PTEN, a tumor suppressor gene located at 10q23, has been shown to be mutated or deleted in a variety of solid tumors. In this study, loss of PTEN expression was evaluated immunohistochemically in 102 patients with DLBCL. Partial or complete loss of PTEN was detected in about one-third of the cases, leading to the conclusion that it might contribute to the lymphomagenesis in some cases.

AB - Diffuse large B-cell lymphomas (DLBCL) constitute the largest subgroup of non-Hodgkin lymphomas (NHL) in adults. Although the etiology of NHL is not fully understood, different genetic abnormalities, involving particularly oncogenes, were shown as a mechanism of lymphomagenesis. Mutations of tumor suppressor genes, unlike oncogenes, have been relatively less studied in DLBCL. PTEN, a tumor suppressor gene located at 10q23, has been shown to be mutated or deleted in a variety of solid tumors. In this study, loss of PTEN expression was evaluated immunohistochemically in 102 patients with DLBCL. Partial or complete loss of PTEN was detected in about one-third of the cases, leading to the conclusion that it might contribute to the lymphomagenesis in some cases.

KW - Tumor-suppressor

KW - 3-kinase/akt pathway

KW - Germline mutations

KW - Pten/mmac1

KW - Gene

KW - Phosphatase

KW - Breast

KW - Cancer

UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=performanshacettepe&SrcAuth=WosAPI&KeyUT=WOS:000188281400022&DestLinkType=FullRecord&DestApp=WOS_CPL

M3 - Conference contribution

SN - 88-323-3147-0

SP - 125

EP - 131

BT - Proceedings Of The Xvii Meeting International Society Of Haematology (european And African Division)

A2 - Linkesch, W

PB - Medimond S R L

T2 - 17th European and African Division Meeting of the International-Society-of-Haematology

Y2 - 7 September 2003 through 10 September 2003

ER -

PTEN expression in diffuse large B-cell lymphomas

Abstract

Conference

UN SDGs

Keywords

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Cite this