TY - JOUR
T1 - Predictors of uveitic macular edema and functional prognostic outcomes
T2 - real-life data from the international AIDA Network uveitis registry
AU - Sota, Jurgen
AU - Mejia-Salgado, German
AU - Guerriero, Silvana
AU - Ragab, Gaafar
AU - Costi, Stefania
AU - Paroli, Maria Pia
AU - Hinojosa-Azaola, Andrea
AU - Lopalco, Giuseppe
AU - Breda, Luciana
AU - Giardini, Henrique Ayres Mayrink
AU - Fonollosa, Alex
AU - Chimenti, Maria Sole
AU - Vitale, Antonio
AU - Gaggiano, Carla
AU - Aguilar-Barrera, Blanca
AU - Rodriguez-Camelo, Laura Daniela
AU - Guaracha-Basanez, Guillermo Arturo
AU - Hegazy, Mohamed Tharwat
AU - Dammacco, Rosanna
AU - Albano, Valeria
AU - Martin-Nares, Eduardo
AU - Espinosa-Lugo, Santiago
AU - Ghanema, Mahmoud
AU - Morrone, Maria
AU - La Bella, Saverio
AU - Cordeiro, Rafael Alves
AU - Carubbi, Francesco
AU - Conforti, Alessandro
AU - Ruscitti, Piero
AU - AlMaglouth, Ibrahim
AU - Talarico, Rosaria
AU - Gentileschi, Stefano
AU - Sfikakis, Petros P.
AU - Caggiano, Valeria
AU - Piga, Matteo
AU - Civino, Adele
AU - Ricci, Francesca
AU - Thabet, Maissa
AU - Govoni, Marcello
AU - Tufan, Abdurrahman
AU - Crisafulli, Francesca
AU - Sbalchiero, Jessica
AU - Al-Mayouf, Sulaiman M.
AU - Mauro, Angela
AU - Hashad, Soad
AU - Minoia, Francesca
AU - Olivieri, Alma Nunzia
AU - Tharwat, Samar
AU - Maggio, Maria Cristina
AU - Moshrif, Abdelhfeez
AU - Sebastiani, Gian Domenico
AU - Opris-Belinski, Daniela
AU - Hatemi, Gulen
AU - Direskeneli, Haner
AU - Alibaz-Oner, Fatma
AU - Fotis, Lampros
AU - Hernandez-Rodriguez, Jose
AU - Conti, Giovanni
AU - Puttini, Piercarlo Sarzi
AU - Viapiana, Ombretta
AU - Giardina, Annarita
AU - Barone, Patrizia
AU - Babu, Kalpana
AU - Amin, Rana Hussein
AU - Kawakami-Campos, Perla Ayumi
AU - Gupta, Vishali
AU - Iagnocco, Annamaria
AU - Sahin, Ali
AU - Insalaco, Antonella
AU - Gonzalez-Garcia, Andres
AU - Batu, Ezgi Deniz
AU - Carreno, Ester
AU - Del Giudice, Emanuela
AU - Chighizola, Cecilia Beatrice
AU - Conti, Fabrizio
AU - Balistreri, Alberto
AU - Frediani, Bruno
AU - Cantarini, Luca
AU - de-la-Torre, Alejandra
AU - Fabiani, Claudia
N1 - Publisher Copyright:
Copyright © 2025 Sota, Mejía-Salgado, Guerriero, Ragab, Costi, Paroli, Hinojosa-Azaola, Lopalco, Breda, Giardini, Fonollosa, Chimenti, Vitale, Gaggiano, Aguilar-Barrera, Rodríguez-Camelo, Guaracha-Basañez, Hegazy, Dammacco, Albano, Martín-Nares, Espinosa-Lugo, Ghanema, Morrone, La Bella, Cordeiro, Carubbi, Conforti, Ruscitti, AlMaglouth, Talarico, Gentileschi, Sfikakis, Caggiano, Piga, Civino, Ricci, Thabet, Govoni, Tufan, Crisafulli, Sbalchiero, Al-Mayouf, Mauro, Hashad, Minoia, Olivieri, Tharwat, Maggio, Moshrif, Sebastiani, Opris-Belinski, Hatemi, Direskeneli, Alibaz-Öner, Fotis, Hernández-Rodríguez, Conti, Puttini, Viapiana, Giardina, Barone, Babu, Amin, Kawakami-Campos, Gupta, Iagnocco, Şahin, Insalaco, González-García, Batu, Carreño, Del Giudice, Chighizola, Conti, Balistreri, Frediani, Cantarini, de-la-Torre and Fabiani.
PY - 2025
Y1 - 2025
N2 - Objectives: To detect factors capable of predicting the development of macular edema (ME) throughout the disease course in patients affected by non-infectious uveitis (NIU). Methods: Predictive factors leading to the development of ME were analyzed through regression analysis. The functional impact of ME on best corrected visual acuity (BCVA) was also examined. Results: A total of 1,160 NIU patients (1,857 eyes) were analyzed. ME was observed in 148 (12.76%), affecting 211 eyes. It was significantly more frequent in patients with non-anterior NIU (p < 0.0001, RR = 4.01), retinal vasculitis (p < 0.0001), and other structural complications (p = 0.0005). Gender, HLA-B*27 and/or HLA-B*51 positivity, and ethnicity did not show any significant impact on the prevalence of ME (p = 0.635, p = 0.372, p = 0.193, respectively). Four variables were associated with ME development during NIU course: the non–anterior anatomical pattern (p < 0.0001, OR = 4.01), the presence of retinal vasculitis (p = 0.028, OR = 1.68), complications other than ME (p = 0.044, OR = 1.51) and immunosuppressive treatment (p = 0.010, OR 1.69) while the diagnosis of Behçet disease-related uveitis was less likely to be associated with ME development (p = 0.24, OR 0.545). Mean ± SD BCVA was significantly lower in eyes with ME (0.82 ± 0.30) compared to eyes without ME (0.71 ± 0.33). Conclusion: ME can develop across all NIU types, but is more likely in cases involving the posterior segment and retinal vasculitis. Regular and focused monitoring is recommended for these high-risk patients. The study also highlights the limited predictive value of demographic and HLA-related factors, helping refine clinical risk stratification and predictive modeling in NIU.
AB - Objectives: To detect factors capable of predicting the development of macular edema (ME) throughout the disease course in patients affected by non-infectious uveitis (NIU). Methods: Predictive factors leading to the development of ME were analyzed through regression analysis. The functional impact of ME on best corrected visual acuity (BCVA) was also examined. Results: A total of 1,160 NIU patients (1,857 eyes) were analyzed. ME was observed in 148 (12.76%), affecting 211 eyes. It was significantly more frequent in patients with non-anterior NIU (p < 0.0001, RR = 4.01), retinal vasculitis (p < 0.0001), and other structural complications (p = 0.0005). Gender, HLA-B*27 and/or HLA-B*51 positivity, and ethnicity did not show any significant impact on the prevalence of ME (p = 0.635, p = 0.372, p = 0.193, respectively). Four variables were associated with ME development during NIU course: the non–anterior anatomical pattern (p < 0.0001, OR = 4.01), the presence of retinal vasculitis (p = 0.028, OR = 1.68), complications other than ME (p = 0.044, OR = 1.51) and immunosuppressive treatment (p = 0.010, OR 1.69) while the diagnosis of Behçet disease-related uveitis was less likely to be associated with ME development (p = 0.24, OR 0.545). Mean ± SD BCVA was significantly lower in eyes with ME (0.82 ± 0.30) compared to eyes without ME (0.71 ± 0.33). Conclusion: ME can develop across all NIU types, but is more likely in cases involving the posterior segment and retinal vasculitis. Regular and focused monitoring is recommended for these high-risk patients. The study also highlights the limited predictive value of demographic and HLA-related factors, helping refine clinical risk stratification and predictive modeling in NIU.
KW - Macular edema
KW - Registries
KW - Retinal vasculitis
KW - Uveitis
KW - Visual acuity
UR - https://www.scopus.com/pages/publications/105021493671
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=performanshacettepe&SrcAuth=WosAPI&KeyUT=WOS:001550619600001&DestLinkType=FullRecord&DestApp=WOS_CPL
U2 - 10.3389/fmed.2025.1609613
DO - 10.3389/fmed.2025.1609613
M3 - Article
C2 - 40809444
SN - 2296-858X
VL - 12
SP - 1609613
JO - Frontiers in Medicine
JF - Frontiers in Medicine
M1 - 1609613
ER -