Organoklorlu Pestisitler, Poliklorlu Bifenilller ve Kahve Tüketimi ile Pankreas Kanseri Arasındaki İlişkinin Değerlendirilmesi

Pancreatic cancer is a cancer type with very high mortality risk and the risk factors, which lead to pancreatic cancer are not definitely enlightened. In its development, genetic factors, particularly K-Ras gene mutations are suggested to play an important role. Some pesticides were identified as causes of pancreatic cancer in both laboratory animals and epidemiological studies have shown that pesticide exposure could increase the risk of pancreatic cancer in farm workers. Limited number of studies indicated that acute or chronic exposure to organochloride pesticides (OC) could cause oxidative stress, which might then lead to diabetes, other metabolic diseases and pancreatic cancer. On the other hand, few studies in literature have found a relationship between exposure to polychlorinated biphenyls (PCBs), high coffee consumption and pancreatic cancer. The aim of this review is to elucidate the relationship between pancreatic cancer, OC and PCB exposure and high coffee consumption.