Molecularly imprinted polymers as a tool for biomolecule separation

The publications in molecularly imprinted materials have increased drastically in recent years, with the development of polymerization systems. The memory in shape, interaction and size of binding cavities has allowed the use of these materials within different applications, particularly in affinity purification and separation in chromatography, sample preparation, and detection in biosensors. Due to their high selectivity, specificity, efficient mass transfer and good reproducibility, molecularly imprinted materials have become attractive for researchers in biomolecular and biomacromolecular recognition. In this review, the recent developments of molecularly imprinted materials in affinity separation and purification systems are reviewed comprehensively. Some significant applications were also highlighted for further investigation.