@inproceedings{c956ab14536e476189aba9fb38e73107,
title = "Measurement of shear-induced diffusion of red blood cells using dynamic light scattering-optical coherence tomography",
abstract = "Dynamic Light Scattering-Optical Coherence Tomography (DLS-OCT) takes the advantages of using DLS to measure particle flow and diffusion within an OCT resolution-constrained 3D volume, enabling the simultaneous measurements of absolute RBC velocity and diffusion coefficient with high spatial resolution. In this work, we applied DLS-OCT to measure both RBC velocity and the shear-induced diffusion coefficient within penetrating venules of the somatosensory cortex of anesthetized mice. Blood flow laminar profile measurements indicate a blunted laminar flow profile, and the degree of blunting decreases with increasing vessel diameter. The measured shear-induced diffusion coefficient was proportional to the flow shear rate with a magnitude of ∼ 0.1 to 0.5 × 10-6mm2. These results provide important experimental support for the recent theoretical explanation for why DCS is dominantly sensitive to RBC diffusive motion.",
keywords = "Blood flow and radial profile, Dynamic light scattering optical coherent tomography, Shear-induced diffusion of RBC",
author = "Jianbo Tang and Erdener, \{Sefik Evren\} and Baoqiang Li and Buyin Fu and Sava Sakadzic and Carp, \{Stefan A.\} and Jonghwan Lee and Boas, \{David A.\}",
note = "Publisher Copyright: {\textcopyright} COPYRIGHT SPIE.; Neural Imaging and Sensing 2018 ; Conference date: 29-01-2018 Through 30-01-2018",
year = "2018",
doi = "10.1117/12.2290345",
language = "English",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Qingming Luo and Jun Ding",
booktitle = "Neural Imaging and Sensing 2018",
address = "United States",
}