MAO-A inhibition profiles of some benzophenone glucosides from Gentiana verna subsp. pontica

Duygu Kaya; Anna K. Jäger; Funda N. Yalçin; Tayfun Ersöz

doi:10.1177/1934578x1400900420

MAO-A inhibition profiles of some benzophenone glucosides from Gentiana verna subsp. pontica

Duygu Kaya
, Anna K. Jäger
, Funda N. Yalçin
, Tayfun Ersöz

Division of Pharmacognosy (Pharmacy)

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Gentiana verna L. subsp. pontica (Soltok.) Hayek, G. pyrenaica L., and G. verna L. subsp. balcanica Pritchard from Turkey were tested for their MAO-A inhibitory effects. A photometric peroxidase linked MAO-A bioassay performed on the H₂O extracts prepared from the methanolic extracts of the title plants revealed the potential effect of G. verna subsp. pontica and three benzophenone glucosides; 2,3′-dihydroxy-4-methoxy-benzophenone-6-O-β- glucopyranoside (1), 2,4,3′,4′-tetrahydroxy-benzophenone-6-O-β- glucopyranoside (maclurin-6-O-β-glucopyranoside) (2) and 2,4,3′-trihydroxy-benzophenone-6-O-β-glucopyranoside (3) isolated from G. verna subsp. pontica. Among the benzophenone glucosides 1 and 2 exhibited significant inhibition of MAO-A (IC₅₀=31.3±4 μM and 41±4.7 μM resp.).

Original language	English
Pages (from-to)	505-506
Number of pages	2
Journal	Natural Product Communications
Volume	9
Issue number	4
DOIs	https://doi.org/10.1177/1934578x1400900420
Publication status	Published - Apr 2014

Keywords

Benzophenone glucosides
Gentiana verna subsp. pontica
MAO-A inhibition

Access to Document

10.1177/1934578x1400900420

Cite this

@article{ba5be4d629b94313842ba4981359d021,

title = "MAO-A inhibition profiles of some benzophenone glucosides from Gentiana verna subsp. pontica",

abstract = "Gentiana verna L. subsp. pontica (Soltok.) Hayek, G. pyrenaica L., and G. verna L. subsp. balcanica Pritchard from Turkey were tested for their MAO-A inhibitory effects. A photometric peroxidase linked MAO-A bioassay performed on the H2O extracts prepared from the methanolic extracts of the title plants revealed the potential effect of G. verna subsp. pontica and three benzophenone glucosides; 2,3′-dihydroxy-4-methoxy-benzophenone-6-O-β- glucopyranoside (1), 2,4,3′,4′-tetrahydroxy-benzophenone-6-O-β- glucopyranoside (maclurin-6-O-β-glucopyranoside) (2) and 2,4,3′-trihydroxy-benzophenone-6-O-β-glucopyranoside (3) isolated from G. verna subsp. pontica. Among the benzophenone glucosides 1 and 2 exhibited significant inhibition of MAO-A (IC50=31.3±4 μM and 41±4.7 μM resp.).",

keywords = "Benzophenone glucosides, Gentiana verna subsp. pontica, MAO-A inhibition",

author = "Duygu Kaya and J{\"a}ger, \{Anna K.\} and Yal{\c c}in, \{Funda N.\} and Tayfun Ers{\"o}z",

year = "2014",

month = apr,

doi = "10.1177/1934578x1400900420",

language = "English",

volume = "9",

pages = "505--506",

journal = "Natural Product Communications",

issn = "1934-578X",

publisher = "SAGE Publications Inc.",

number = "4",

}

TY - JOUR

T1 - MAO-A inhibition profiles of some benzophenone glucosides from Gentiana verna subsp. pontica

AU - Kaya, Duygu

AU - Jäger, Anna K.

AU - Yalçin, Funda N.

AU - Ersöz, Tayfun

PY - 2014/4

Y1 - 2014/4

N2 - Gentiana verna L. subsp. pontica (Soltok.) Hayek, G. pyrenaica L., and G. verna L. subsp. balcanica Pritchard from Turkey were tested for their MAO-A inhibitory effects. A photometric peroxidase linked MAO-A bioassay performed on the H2O extracts prepared from the methanolic extracts of the title plants revealed the potential effect of G. verna subsp. pontica and three benzophenone glucosides; 2,3′-dihydroxy-4-methoxy-benzophenone-6-O-β- glucopyranoside (1), 2,4,3′,4′-tetrahydroxy-benzophenone-6-O-β- glucopyranoside (maclurin-6-O-β-glucopyranoside) (2) and 2,4,3′-trihydroxy-benzophenone-6-O-β-glucopyranoside (3) isolated from G. verna subsp. pontica. Among the benzophenone glucosides 1 and 2 exhibited significant inhibition of MAO-A (IC50=31.3±4 μM and 41±4.7 μM resp.).

AB - Gentiana verna L. subsp. pontica (Soltok.) Hayek, G. pyrenaica L., and G. verna L. subsp. balcanica Pritchard from Turkey were tested for their MAO-A inhibitory effects. A photometric peroxidase linked MAO-A bioassay performed on the H2O extracts prepared from the methanolic extracts of the title plants revealed the potential effect of G. verna subsp. pontica and three benzophenone glucosides; 2,3′-dihydroxy-4-methoxy-benzophenone-6-O-β- glucopyranoside (1), 2,4,3′,4′-tetrahydroxy-benzophenone-6-O-β- glucopyranoside (maclurin-6-O-β-glucopyranoside) (2) and 2,4,3′-trihydroxy-benzophenone-6-O-β-glucopyranoside (3) isolated from G. verna subsp. pontica. Among the benzophenone glucosides 1 and 2 exhibited significant inhibition of MAO-A (IC50=31.3±4 μM and 41±4.7 μM resp.).

KW - Benzophenone glucosides

KW - Gentiana verna subsp. pontica

KW - MAO-A inhibition

UR - https://www.scopus.com/pages/publications/84898826265

UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=performanshacettepe&SrcAuth=WosAPI&KeyUT=WOS:000335083500020&DestLinkType=FullRecord&DestApp=WOS_CPL

U2 - 10.1177/1934578x1400900420

DO - 10.1177/1934578x1400900420

M3 - Article

C2 - 24868869

AN - SCOPUS:84898826265

SN - 1934-578X

VL - 9

SP - 505

EP - 506

JO - Natural Product Communications

JF - Natural Product Communications

IS - 4

ER -

MAO-A inhibition profiles of some benzophenone glucosides from Gentiana verna subsp. pontica

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this