Liken planusda oksidatif stres parametreleri ve dislipideminin oksidatif stres parametreleri üzerine etkisi

Arzu Kiliç; Serpil Erdoğan; Ahu Yorulmaz; Sibel Doğan; Merve Ergin; Ferda Artüz; Özcan Erel

doi:10.4274/turkderm.74317

Liken planusda oksidatif stres parametreleri ve dislipideminin oksidatif stres parametreleri üzerine etkisi

Translated title of the contribution: The oxidative stress parameters and the effect of dyslipidemia on the parameters of oxidative stress in lichen planus

Arzu Kiliç
, Serpil Erdoğan
, Ahu Yorulmaz
, Sibel Doğan
, Merve Ergin
, Ferda Artüz
, Özcan Erel

Division of Dermatological and Venereal Diseases

Balikesir University
Atatürk Training and Research Hospital
Ankara Numune Education and Research Hospital
Biyokimya Kliniği
Hitit University

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Background and Design: Various reports have demonstrated an association between inflammatory skin disorders and oxidative stress. Additionally, dyslipidemia and systemic disorders have been found to associate with chronic inflammatory skin diseases. In this study, we aimed to investigate the oxidative stress parameters and the effect of dyslipidemia on the parameters of oxidative stress in lichen planus (LP). Materials and Methods: Fifty-four patients with LP and 60 control subjects were enrolled in the study. Total cholesterol, triglyceride, highdensity lipoprotein cholesterol (HDL-C), low-de nsity lipoprotein cholesterol (LDL-C), and very low density lipoprotein cholesterol (VLDL-C) levels were studied in all participants. After participants with associated systemic diseases were excluded, total antioxidant status (TAS), paraoxonase (PON), arylesterease, stimulated PON and total thiol levels (TTL) levels were studied in 36 patients with LP and control group. Results: 62.96% of the patients were detected to have dyslipidemia. Total cholesterol and LDL-C levels were found to be significantly higher and HDL-C levels were found to be significantly lower in patient group when compared with control group. Serum TAS was found to be significantly lower in patient group than in control group. When patients with dyslipidemia were compared with patients without dyslipidemia in terms of oxidative stress parameters, serum level of TTL was found to be lower in patients with dyslipidemia. Conclusion: In this study, LP was associated with dyslipidemia. Besides, our findings showed that decreased TAS activity might have a role in the pathogenesis of LP. Our findings support that associated dyslipidemia may contribute to the etiopathogenesis of LP by reducing the antioxidant defense. Prospective studies with larger samples are needed to enlighten the possible effects of dyslipidemia on the incidence, mechanism and severity of LP.

Translated title of the contribution	The oxidative stress parameters and the effect of dyslipidemia on the parameters of oxidative stress in lichen planus
Original language	Turkish
Pages (from-to)	7-12
Number of pages	6
Journal	Turkderm Deri Hastaliklari ve Frengi Arsivi
Volume	49
DOIs	https://doi.org/10.4274/turkderm.74317
Publication status	Published - 2015

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10.4274/turkderm.74317

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@article{27a26978d6ed474e89f15bc59a599169,

title = "Liken planusda oksidatif stres parametreleri ve dislipideminin oksidatif stres parametreleri {\"u}zerine etkisi",

abstract = "Background and Design: Various reports have demonstrated an association between inflammatory skin disorders and oxidative stress. Additionally, dyslipidemia and systemic disorders have been found to associate with chronic inflammatory skin diseases. In this study, we aimed to investigate the oxidative stress parameters and the effect of dyslipidemia on the parameters of oxidative stress in lichen planus (LP). Materials and Methods: Fifty-four patients with LP and 60 control subjects were enrolled in the study. Total cholesterol, triglyceride, highdensity lipoprotein cholesterol (HDL-C), low-de nsity lipoprotein cholesterol (LDL-C), and very low density lipoprotein cholesterol (VLDL-C) levels were studied in all participants. After participants with associated systemic diseases were excluded, total antioxidant status (TAS), paraoxonase (PON), arylesterease, stimulated PON and total thiol levels (TTL) levels were studied in 36 patients with LP and control group. Results: 62.96\% of the patients were detected to have dyslipidemia. Total cholesterol and LDL-C levels were found to be significantly higher and HDL-C levels were found to be significantly lower in patient group when compared with control group. Serum TAS was found to be significantly lower in patient group than in control group. When patients with dyslipidemia were compared with patients without dyslipidemia in terms of oxidative stress parameters, serum level of TTL was found to be lower in patients with dyslipidemia. Conclusion: In this study, LP was associated with dyslipidemia. Besides, our findings showed that decreased TAS activity might have a role in the pathogenesis of LP. Our findings support that associated dyslipidemia may contribute to the etiopathogenesis of LP by reducing the antioxidant defense. Prospective studies with larger samples are needed to enlighten the possible effects of dyslipidemia on the incidence, mechanism and severity of LP.",

keywords = "Dyslipidemia, Lichen planus, Oxidative stress",

author = "Arzu Kili{\c c} and Serpil Erdoğan and Ahu Yorulmaz and Sibel Doğan and Merve Ergin and Ferda Art{\"u}z and {\"O}zcan Erel",

year = "2015",

doi = "10.4274/turkderm.74317",

language = "T{\"u}rk{\c c}e",

volume = "49",

pages = "7--12",

journal = "Turkderm Deri Hastaliklari ve Frengi Arsivi",

issn = "1019-214X",

publisher = "Istanbul Assoc. of Dermatology and Venerology",

}

TY - JOUR

T1 - Liken planusda oksidatif stres parametreleri ve dislipideminin oksidatif stres parametreleri üzerine etkisi

AU - Kiliç, Arzu

AU - Erdoğan, Serpil

AU - Yorulmaz, Ahu

AU - Doğan, Sibel

AU - Ergin, Merve

AU - Artüz, Ferda

AU - Erel, Özcan

PY - 2015

Y1 - 2015

N2 - Background and Design: Various reports have demonstrated an association between inflammatory skin disorders and oxidative stress. Additionally, dyslipidemia and systemic disorders have been found to associate with chronic inflammatory skin diseases. In this study, we aimed to investigate the oxidative stress parameters and the effect of dyslipidemia on the parameters of oxidative stress in lichen planus (LP). Materials and Methods: Fifty-four patients with LP and 60 control subjects were enrolled in the study. Total cholesterol, triglyceride, highdensity lipoprotein cholesterol (HDL-C), low-de nsity lipoprotein cholesterol (LDL-C), and very low density lipoprotein cholesterol (VLDL-C) levels were studied in all participants. After participants with associated systemic diseases were excluded, total antioxidant status (TAS), paraoxonase (PON), arylesterease, stimulated PON and total thiol levels (TTL) levels were studied in 36 patients with LP and control group. Results: 62.96% of the patients were detected to have dyslipidemia. Total cholesterol and LDL-C levels were found to be significantly higher and HDL-C levels were found to be significantly lower in patient group when compared with control group. Serum TAS was found to be significantly lower in patient group than in control group. When patients with dyslipidemia were compared with patients without dyslipidemia in terms of oxidative stress parameters, serum level of TTL was found to be lower in patients with dyslipidemia. Conclusion: In this study, LP was associated with dyslipidemia. Besides, our findings showed that decreased TAS activity might have a role in the pathogenesis of LP. Our findings support that associated dyslipidemia may contribute to the etiopathogenesis of LP by reducing the antioxidant defense. Prospective studies with larger samples are needed to enlighten the possible effects of dyslipidemia on the incidence, mechanism and severity of LP.

AB - Background and Design: Various reports have demonstrated an association between inflammatory skin disorders and oxidative stress. Additionally, dyslipidemia and systemic disorders have been found to associate with chronic inflammatory skin diseases. In this study, we aimed to investigate the oxidative stress parameters and the effect of dyslipidemia on the parameters of oxidative stress in lichen planus (LP). Materials and Methods: Fifty-four patients with LP and 60 control subjects were enrolled in the study. Total cholesterol, triglyceride, highdensity lipoprotein cholesterol (HDL-C), low-de nsity lipoprotein cholesterol (LDL-C), and very low density lipoprotein cholesterol (VLDL-C) levels were studied in all participants. After participants with associated systemic diseases were excluded, total antioxidant status (TAS), paraoxonase (PON), arylesterease, stimulated PON and total thiol levels (TTL) levels were studied in 36 patients with LP and control group. Results: 62.96% of the patients were detected to have dyslipidemia. Total cholesterol and LDL-C levels were found to be significantly higher and HDL-C levels were found to be significantly lower in patient group when compared with control group. Serum TAS was found to be significantly lower in patient group than in control group. When patients with dyslipidemia were compared with patients without dyslipidemia in terms of oxidative stress parameters, serum level of TTL was found to be lower in patients with dyslipidemia. Conclusion: In this study, LP was associated with dyslipidemia. Besides, our findings showed that decreased TAS activity might have a role in the pathogenesis of LP. Our findings support that associated dyslipidemia may contribute to the etiopathogenesis of LP by reducing the antioxidant defense. Prospective studies with larger samples are needed to enlighten the possible effects of dyslipidemia on the incidence, mechanism and severity of LP.

KW - Dyslipidemia

KW - Lichen planus

KW - Oxidative stress

UR - https://www.scopus.com/pages/publications/84962238110

U2 - 10.4274/turkderm.74317

DO - 10.4274/turkderm.74317

M3 - Makale

AN - SCOPUS:84962238110

SN - 1019-214X

VL - 49

SP - 7

EP - 12

JO - Turkderm Deri Hastaliklari ve Frengi Arsivi

JF - Turkderm Deri Hastaliklari ve Frengi Arsivi

ER -

Liken planusda oksidatif stres parametreleri ve dislipideminin oksidatif stres parametreleri üzerine etkisi

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