Kendiliğinden Emülsifiye Olabilen İlaç Taşıyıcı Sistemler ve Farmasötik Alanda Uygulamaları

Self emulsifying drug delivery systems (SEDDS) are isotropic mixtures which contain surfactant, oil and cosolvents and they are used for drug delivery, enhanced bioavailability of poorly soluble drugs and lymphatic drug targeting. SEDDS are prepared using ternary phase diagrams and high throughput screening systems with spesific ratios of excipients. Various poorly soluble drugs which have different pharmacological activities and peptide/protein drugs can be entrapped in SEDDS. By this way, drugs which have solubility or stability problems can be formulated with SEDDS and oral route could be possible for administration. Sandimmune Neoral^® (Cyclosporine A), Norvir^® (Ritonavir) and Fortovase^® (Saquinavir) are products on the pharmaceutical market which are formulated with SEDDS formulations and have improved oral bioavailability. Liquid SEDDS formulations can be filled into hard or soft gelatine capsules and solid SEDDS can be prepared by spray drying which have more microbiological stability. Because of increased interest in SEDDS, new drug compounds can be formulated and marketed or they can be used more efficiently like lower dose, enhanced stability or oral administration.