Abstract
Recent articles about the roles and relationships of tissue inhibitor of metalloproteinase-1 and transforming growth factor-beta 1 in various types of normal tissues and malignancies give rise to the question: 'Is there a relationship between them with regard to malignant melanoma progression?' In the light of many references, it seems to be highly probable that the tissue inhibitor of metalloproteinase-1, - being a multifunctional protein functions as a growth factor with possible stimulation by transforming growth factor-beta 1 in progression of malignant melanoma, rather than its other existing functions in many different normal and cancer tissues (e.g. inhibition of the matrix metalloproteinases or functioning as an insignificant inhibitor of angiogenesis).
| Original language | English |
|---|---|
| Pages (from-to) | 238-240 |
| Number of pages | 3 |
| Journal | Medical Hypotheses |
| Volume | 57 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2001 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
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