Investigation of myorelaxant activity of 9-aryl-3,4,6,7-tetrahydroacridine- 1,8-(2H,5H,9H,10H)-diones in isolated rabbit gastric fundus

Gökçe Sevim Öztürk Fincan; Miyase Gözde Gündüz; Ismail Mert Vural; Rahime Şimşek; Yusuf Sarioǧlu; Cihat Şafak

doi:10.1007/s00044-011-9698-x

Investigation of myorelaxant activity of 9-aryl-3,4,6,7-tetrahydroacridine- 1,8-(2H,5H,9H,10H)-diones in isolated rabbit gastric fundus

Gökçe Sevim Öztürk Fincan
, Miyase Gözde Gündüz
, Ismail Mert Vural
, Rahime Şimşek
, Yusuf Sarioǧlu
, Cihat Şafak

Division of Pharmaceutical Chemistry (Pharmacy)

Gazi University
Hacettepe University

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

In this study, twelve compounds having 9-aryl- 3,4,6,7-tetrahydroacridine- 1,8-(2H,5H,9H,10H)-dione structure were synthesized by reaction of 5-methyl-1,3-cyclohexanedione, the appropriate aromatic aldehydes, and ammonium acetate in methanol. The structures of the compounds were elucidated by infrared, ¹H- and ¹³Cnuclear magnetic resonance spectroscopy (-NMR), mass spectroscopy, and elemental analysis. The maximum relaxant effects (E _max) and pD2 values of the compounds 3a-l and pinacidil were tested on isolated strips of rabbit gastric fundus smooth muscle.

Original language	English
Pages (from-to)	1817-1824
Number of pages	8
Journal	Medicinal Chemistry Research
Volume	21
Issue number	8
DOIs	https://doi.org/10.1007/s00044-011-9698-x
Publication status	Published - Aug 2012

Keywords

Acridinedione
Myorelaxant activity
Pinacidil

Access to Document

10.1007/s00044-011-9698-x

Cite this

@article{40251110dd5244a191aa1e3e4f781381,

title = "Investigation of myorelaxant activity of 9-aryl-3,4,6,7-tetrahydroacridine- 1,8-(2H,5H,9H,10H)-diones in isolated rabbit gastric fundus",

abstract = "In this study, twelve compounds having 9-aryl- 3,4,6,7-tetrahydroacridine- 1,8-(2H,5H,9H,10H)-dione structure were synthesized by reaction of 5-methyl-1,3-cyclohexanedione, the appropriate aromatic aldehydes, and ammonium acetate in methanol. The structures of the compounds were elucidated by infrared, 1H- and 13Cnuclear magnetic resonance spectroscopy (-NMR), mass spectroscopy, and elemental analysis. The maximum relaxant effects (E max) and pD2 values of the compounds 3a-l and pinacidil were tested on isolated strips of rabbit gastric fundus smooth muscle.",

keywords = "Acridinedione, Myorelaxant activity, Pinacidil",

author = "Fincan, \{G{\"o}k{\c c}e Sevim {\"O}zt{\"u}rk\} and G{\"u}nd{\"u}z, \{Miyase G{\"o}zde\} and Vural, \{Ismail Mert\} and Rahime {\c S}im{\c s}ek and Yusuf Sarioǧlu and Cihat {\c S}afak",

year = "2012",

month = aug,

doi = "10.1007/s00044-011-9698-x",

language = "English",

volume = "21",

pages = "1817--1824",

journal = "Medicinal Chemistry Research",

issn = "1054-2523",

publisher = "Springer",

number = "8",

}

TY - JOUR

T1 - Investigation of myorelaxant activity of 9-aryl-3,4,6,7-tetrahydroacridine- 1,8-(2H,5H,9H,10H)-diones in isolated rabbit gastric fundus

AU - Fincan, Gökçe Sevim Öztürk

AU - Gündüz, Miyase Gözde

AU - Vural, Ismail Mert

AU - Şimşek, Rahime

AU - Sarioǧlu, Yusuf

AU - Şafak, Cihat

PY - 2012/8

Y1 - 2012/8

N2 - In this study, twelve compounds having 9-aryl- 3,4,6,7-tetrahydroacridine- 1,8-(2H,5H,9H,10H)-dione structure were synthesized by reaction of 5-methyl-1,3-cyclohexanedione, the appropriate aromatic aldehydes, and ammonium acetate in methanol. The structures of the compounds were elucidated by infrared, 1H- and 13Cnuclear magnetic resonance spectroscopy (-NMR), mass spectroscopy, and elemental analysis. The maximum relaxant effects (E max) and pD2 values of the compounds 3a-l and pinacidil were tested on isolated strips of rabbit gastric fundus smooth muscle.

AB - In this study, twelve compounds having 9-aryl- 3,4,6,7-tetrahydroacridine- 1,8-(2H,5H,9H,10H)-dione structure were synthesized by reaction of 5-methyl-1,3-cyclohexanedione, the appropriate aromatic aldehydes, and ammonium acetate in methanol. The structures of the compounds were elucidated by infrared, 1H- and 13Cnuclear magnetic resonance spectroscopy (-NMR), mass spectroscopy, and elemental analysis. The maximum relaxant effects (E max) and pD2 values of the compounds 3a-l and pinacidil were tested on isolated strips of rabbit gastric fundus smooth muscle.

KW - Acridinedione

KW - Myorelaxant activity

KW - Pinacidil

UR - https://www.scopus.com/pages/publications/84866109269

U2 - 10.1007/s00044-011-9698-x

DO - 10.1007/s00044-011-9698-x

M3 - Article

AN - SCOPUS:84866109269

SN - 1054-2523

VL - 21

SP - 1817

EP - 1824

JO - Medicinal Chemistry Research

JF - Medicinal Chemistry Research

IS - 8

ER -

Investigation of myorelaxant activity of 9-aryl-3,4,6,7-tetrahydroacridine- 1,8-(2H,5H,9H,10H)-diones in isolated rabbit gastric fundus

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this