Interaction of osteoblasts with macroporous scaffolds made of PLLA/PCL blends modified with collagen and hydroxyapatite

Halil Murat Aydin; Ying Yang; Thomas Kohler; Alicia El Haj; Ralph Müller; Erhan Pis̃kin

doi:10.1002/adem.200900030

Interaction of osteoblasts with macroporous scaffolds made of PLLA/PCL blends modified with collagen and hydroxyapatite

Halil Murat Aydin
, Ying Yang
, Thomas Kohler
, Alicia El Haj
, Ralph Müller
, Erhan Pis̃kin

Division of Bioengineering (Interdisciplinary)

Keele University
Swiss Federal Institute of Technology Zurich
Hacettepe University

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

A study was conducted to demonstrate the interaction of osteoblasts with macroporous scaffolds made of poly(L-lactic acid) (PLLA) and poly(ε-caprolactone) (PCL) blends modified with collagen and hydroxyapatite. Interaction of these bioactive scaffolds with significantly high porosity and interconnected pore structures with cells were investigated in cell culture using MG63 osteoblastic cell line. The lower molecular weight PCL in the blend was expected to degrade first and allow cell proliferation. PLLA with much higher molecular weight was used to maintain the structural integrity of the scaffold with significantly high porosity. The scaffold morphology was investigated by field-emission scanning electron microscopy and by microcomputed tomography (microCT). The microtomographic imaging system used in the study was equipped with a 5 μm focal spot X-ray tube as a source.

Original language	English
Pages (from-to)	B83-B88
Journal	Advanced Engineering Materials
Volume	11
Issue number	8
DOIs	https://doi.org/10.1002/adem.200900030
Publication status	Published - Aug 2009

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title = "Interaction of osteoblasts with macroporous scaffolds made of PLLA/PCL blends modified with collagen and hydroxyapatite",

abstract = "A study was conducted to demonstrate the interaction of osteoblasts with macroporous scaffolds made of poly(L-lactic acid) (PLLA) and poly(ε-caprolactone) (PCL) blends modified with collagen and hydroxyapatite. Interaction of these bioactive scaffolds with significantly high porosity and interconnected pore structures with cells were investigated in cell culture using MG63 osteoblastic cell line. The lower molecular weight PCL in the blend was expected to degrade first and allow cell proliferation. PLLA with much higher molecular weight was used to maintain the structural integrity of the scaffold with significantly high porosity. The scaffold morphology was investigated by field-emission scanning electron microscopy and by microcomputed tomography (microCT). The microtomographic imaging system used in the study was equipped with a 5 μm focal spot X-ray tube as a source.",

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AU - Aydin, Halil Murat

AU - Yang, Ying

AU - Kohler, Thomas

AU - Haj, Alicia El

AU - Müller, Ralph

AU - Pis̃kin, Erhan

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AB - A study was conducted to demonstrate the interaction of osteoblasts with macroporous scaffolds made of poly(L-lactic acid) (PLLA) and poly(ε-caprolactone) (PCL) blends modified with collagen and hydroxyapatite. Interaction of these bioactive scaffolds with significantly high porosity and interconnected pore structures with cells were investigated in cell culture using MG63 osteoblastic cell line. The lower molecular weight PCL in the blend was expected to degrade first and allow cell proliferation. PLLA with much higher molecular weight was used to maintain the structural integrity of the scaffold with significantly high porosity. The scaffold morphology was investigated by field-emission scanning electron microscopy and by microcomputed tomography (microCT). The microtomographic imaging system used in the study was equipped with a 5 μm focal spot X-ray tube as a source.

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Interaction of osteoblasts with macroporous scaffolds made of PLLA/PCL blends modified with collagen and hydroxyapatite

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