In vitro activities of antibiotics alone and in combination against Brucella melitensis at neutral and acidic pHs

Murat Akova; Deniz Gür; David M. Livermore; Tanil Kocagöz; H. Erdal Akalin

doi:10.1128/aac.43.5.1298

In vitro activities of antibiotics alone and in combination against Brucella melitensis at neutral and acidic pHs

Murat Akova
, Deniz Gür
, David M. Livermore
, Tanil Kocagöz
, H. Erdal Akalin

Division of Infectious Diseases and Clinical Microbiology

Hacettepe University
UK Health Security Agency
Pfizer

Research output: Contribution to journal › Article › peer-review

77 Citations (Scopus)

Abstract

Brucellae survive acidic pHs in phagolysosomes. Azithromycin, streptomycin, and quinolones were active against Brucella melitensis at pit 7.0 but not at pH 5.0; rifampin and doxycycline retained activity at pH 5.0. Regardless of pH, azithromycin-rifampin and ofloxacin-rifampin showed less synergy than established streptomycin-doxycycline and rifampin-doxycycline combinations.

Original language	English
Pages (from-to)	1298-1300
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	43
Issue number	5
DOIs	https://doi.org/10.1128/aac.43.5.1298
Publication status	Published - May 1999

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SDG 3 Good Health and Well-being

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10.1128/aac.43.5.1298

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abstract = "Brucellae survive acidic pHs in phagolysosomes. Azithromycin, streptomycin, and quinolones were active against Brucella melitensis at pit 7.0 but not at pH 5.0; rifampin and doxycycline retained activity at pH 5.0. Regardless of pH, azithromycin-rifampin and ofloxacin-rifampin showed less synergy than established streptomycin-doxycycline and rifampin-doxycycline combinations.",

author = "Murat Akova and Deniz G{\"u}r and Livermore, \{David M.\} and Tanil Kocag{\"o}z and Akalin, \{H. Erdal\}",

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language = "English",

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AU - Akova, Murat

AU - Gür, Deniz

AU - Livermore, David M.

AU - Kocagöz, Tanil

AU - Akalin, H. Erdal

PY - 1999/5

Y1 - 1999/5

N2 - Brucellae survive acidic pHs in phagolysosomes. Azithromycin, streptomycin, and quinolones were active against Brucella melitensis at pit 7.0 but not at pH 5.0; rifampin and doxycycline retained activity at pH 5.0. Regardless of pH, azithromycin-rifampin and ofloxacin-rifampin showed less synergy than established streptomycin-doxycycline and rifampin-doxycycline combinations.

AB - Brucellae survive acidic pHs in phagolysosomes. Azithromycin, streptomycin, and quinolones were active against Brucella melitensis at pit 7.0 but not at pH 5.0; rifampin and doxycycline retained activity at pH 5.0. Regardless of pH, azithromycin-rifampin and ofloxacin-rifampin showed less synergy than established streptomycin-doxycycline and rifampin-doxycycline combinations.

UR - https://www.scopus.com/pages/publications/0345517292

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DO - 10.1128/aac.43.5.1298

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AN - SCOPUS:0345517292

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JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 5

ER -

In vitro activities of antibiotics alone and in combination against Brucella melitensis at neutral and acidic pHs

Abstract

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