IL-8 contributes to functional diversity of tumor-infiltrating neutrophils: A new target for cancer immunotherapy

Ece Tavukcuoglu; Gunes Esendagli

doi:10.1016/j.devcel.2025.01.003

IL-8 contributes to functional diversity of tumor-infiltrating neutrophils: A new target for cancer immunotherapy

Ece Tavukcuoglu
, Gunes Esendagli

Division of Basic Oncology (Interdisciplinary)

Hacettepe University

Research output: Contribution to journal › Comment/debate

3 Citations (Scopus)

Abstract

In this issue of Developmental Cell, Tang et al. identify CD74^high neutrophils as a subpopulation promoted by IL-8 in the tumor microenvironment of non-small lung cancer (NSCLC). These CD74^high neutrophils support anti-tumor T cell responses and enhance the efficacy of anti-PD-1 immunotherapy and targeted therapy in NSCLC.

Original language	English
Pages (from-to)	339-341
Number of pages	3
Journal	Developmental Cell
Volume	60
Issue number	3
DOIs	https://doi.org/10.1016/j.devcel.2025.01.003
Publication status	Published - 3 Feb 2025

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.devcel.2025.01.003

Cite this

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title = "IL-8 contributes to functional diversity of tumor-infiltrating neutrophils: A new target for cancer immunotherapy",

abstract = "In this issue of Developmental Cell, Tang et al. identify CD74high neutrophils as a subpopulation promoted by IL-8 in the tumor microenvironment of non-small lung cancer (NSCLC). These CD74high neutrophils support anti-tumor T cell responses and enhance the efficacy of anti-PD-1 immunotherapy and targeted therapy in NSCLC.",

author = "Ece Tavukcuoglu and Gunes Esendagli",

note = "Publisher Copyright: {\textcopyright} 2025 Elsevier Inc.",

year = "2025",

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T2 - A new target for cancer immunotherapy

AU - Tavukcuoglu, Ece

AU - Esendagli, Gunes

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N2 - In this issue of Developmental Cell, Tang et al. identify CD74high neutrophils as a subpopulation promoted by IL-8 in the tumor microenvironment of non-small lung cancer (NSCLC). These CD74high neutrophils support anti-tumor T cell responses and enhance the efficacy of anti-PD-1 immunotherapy and targeted therapy in NSCLC.

AB - In this issue of Developmental Cell, Tang et al. identify CD74high neutrophils as a subpopulation promoted by IL-8 in the tumor microenvironment of non-small lung cancer (NSCLC). These CD74high neutrophils support anti-tumor T cell responses and enhance the efficacy of anti-PD-1 immunotherapy and targeted therapy in NSCLC.

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DO - 10.1016/j.devcel.2025.01.003

M3 - Comment/debate

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AN - SCOPUS:85216184790

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JO - Developmental Cell

JF - Developmental Cell

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ER -

IL-8 contributes to functional diversity of tumor-infiltrating neutrophils: A new target for cancer immunotherapy

Abstract

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