Hyaluronan binding assay does not predict pregnancy rates in IUI cycles in couples with unexplained infertility

Purpose: To investigate the relationship between hyaluronan binding (HB) assay and pregnancy rates in intrauterine insemination (IUI) cycles. Methods: This prospective cohort study was done in Hacettepe University, a tertiary care center for reproductive medicine. Seventy-one consecutive couples who suffered from unexplained infertility and underwent controlled ovarian hyperstimulation (COH) and IUI were enrolled into the study. Results: From the 71 IUI patients, the clinical pregnancy rate was 14.1 % (10 of 71). HB ratio from the overall patient number was 48.6 ± 25.9. The mean HB ratio in pregnant and non-pregnant groups was comparable (50.2 ± 25.2 vs. 48.3 ± 26.2, respectively, p > 0.05). Conclusions: Hyaluronan binding assay does not predict pregnancy rates in IUI cycles in couples with unexplained infertility.