Extrahepatic Metabolism and Renal Effects of Sevoflurane in a Case of Liver Transplantation

N. Erdem; M. Kanbak; F. Saricaoǧlu; T. Öcal; C. Tanyel; N. Ertaş; A. Berkkan; Ü Aypar

doi:10.1016/j.transproceed.2006.02.075

Extrahepatic Metabolism and Renal Effects of Sevoflurane in a Case of Liver Transplantation

N. Erdem
, M. Kanbak
, F. Saricaoǧlu
, T. Öcal
, C. Tanyel
, N. Ertaş
, A. Berkkan
, Ü Aypar

Hacettepe University

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

In a case of liver transplantation, sevoflurane metabolism was studied to investigate if sevoflurane has an extrahepatic metabolism or possible nephrotoxicity in the presence of chronic liver disease. Plasma blood urea nitrogen (BUN) and creatinine and urine levels of N-acetyl glycosaminidase (NAG) and β2 microglobulin were assessed intraoperatively and for 11 days postoperatively. We observed a close relation between urine NAG excretion and urine inorganic fluoride levels in the intraoperative period and early postoperative days. The NAG levels were greater than normal despite the peak serum inorganic fluoride concentration of 18.94 μmol/L. No impairment was observed in serum BUN or creatinine levels in these periods.

Original language	English
Pages (from-to)	1463-1466
Number of pages	4
Journal	Transplantation Proceedings
Volume	38
Issue number	5
DOIs	https://doi.org/10.1016/j.transproceed.2006.02.075
Publication status	Published - Jun 2006

Access to Document

10.1016/j.transproceed.2006.02.075

Cite this

@article{f8f1c22a2f5941a09627728ef71dc101,

title = "Extrahepatic Metabolism and Renal Effects of Sevoflurane in a Case of Liver Transplantation",

abstract = "In a case of liver transplantation, sevoflurane metabolism was studied to investigate if sevoflurane has an extrahepatic metabolism or possible nephrotoxicity in the presence of chronic liver disease. Plasma blood urea nitrogen (BUN) and creatinine and urine levels of N-acetyl glycosaminidase (NAG) and β2 microglobulin were assessed intraoperatively and for 11 days postoperatively. We observed a close relation between urine NAG excretion and urine inorganic fluoride levels in the intraoperative period and early postoperative days. The NAG levels were greater than normal despite the peak serum inorganic fluoride concentration of 18.94 μmol/L. No impairment was observed in serum BUN or creatinine levels in these periods.",

author = "N. Erdem and M. Kanbak and F. Saricaoǧlu and T. {\"O}cal and C. Tanyel and N. Erta{\c s} and A. Berkkan and {\"U} Aypar",

year = "2006",

month = jun,

doi = "10.1016/j.transproceed.2006.02.075",

language = "English",

volume = "38",

pages = "1463--1466",

journal = "Transplantation Proceedings",

issn = "0041-1345",

publisher = "Elsevier Inc.",

number = "5",

}

TY - JOUR

T1 - Extrahepatic Metabolism and Renal Effects of Sevoflurane in a Case of Liver Transplantation

AU - Erdem, N.

AU - Kanbak, M.

AU - Saricaoǧlu, F.

AU - Öcal, T.

AU - Tanyel, C.

AU - Ertaş, N.

AU - Berkkan, A.

AU - Aypar, Ü

PY - 2006/6

Y1 - 2006/6

N2 - In a case of liver transplantation, sevoflurane metabolism was studied to investigate if sevoflurane has an extrahepatic metabolism or possible nephrotoxicity in the presence of chronic liver disease. Plasma blood urea nitrogen (BUN) and creatinine and urine levels of N-acetyl glycosaminidase (NAG) and β2 microglobulin were assessed intraoperatively and for 11 days postoperatively. We observed a close relation between urine NAG excretion and urine inorganic fluoride levels in the intraoperative period and early postoperative days. The NAG levels were greater than normal despite the peak serum inorganic fluoride concentration of 18.94 μmol/L. No impairment was observed in serum BUN or creatinine levels in these periods.

AB - In a case of liver transplantation, sevoflurane metabolism was studied to investigate if sevoflurane has an extrahepatic metabolism or possible nephrotoxicity in the presence of chronic liver disease. Plasma blood urea nitrogen (BUN) and creatinine and urine levels of N-acetyl glycosaminidase (NAG) and β2 microglobulin were assessed intraoperatively and for 11 days postoperatively. We observed a close relation between urine NAG excretion and urine inorganic fluoride levels in the intraoperative period and early postoperative days. The NAG levels were greater than normal despite the peak serum inorganic fluoride concentration of 18.94 μmol/L. No impairment was observed in serum BUN or creatinine levels in these periods.

UR - https://www.scopus.com/pages/publications/33745218247

U2 - 10.1016/j.transproceed.2006.02.075

DO - 10.1016/j.transproceed.2006.02.075

M3 - Article

C2 - 16797334

AN - SCOPUS:33745218247

SN - 0041-1345

VL - 38

SP - 1463

EP - 1466

JO - Transplantation Proceedings

JF - Transplantation Proceedings

IS - 5

ER -

Extrahepatic Metabolism and Renal Effects of Sevoflurane in a Case of Liver Transplantation

Abstract

Access to Document

Other files and links

Fingerprint

Cite this