Extracellular Matrix-Based Conductive Composites for Myocardial Tissue Regeneration

Gülçin Günal; Dincer Gokcen; Halil Murat Aydin

doi:10.1021/acsabm.3c00557

Extracellular Matrix-Based Conductive Composites for Myocardial Tissue Regeneration

Gülçin Günal
, Dincer Gokcen
, Halil Murat Aydin

Hacettepe University
Akdeniz University

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Myocardial tissue engineering strategies such as fabrication of cardiac patches for tissue regeneration offer various solutions for the loss of function developed due to myocardial infarction. Here, we combined the hybrid structure (previously obtained and combined decellularized myocardium grafts with poly(glycerol-sebacate) polymer) with multiwalled carbon nanotubes (MWCNTs) to provide the essential characteristics for cardiac tissue regeneration. MWCNTs were doped in the cross-linked structure, and the conductivity and Young’s modulus of the composite elastomer were found as 5 × 10^-3 ± 1 × 10^-3 S/m and 374 ± 75.8 kPa, respectively. The cell-material interaction was evaluated, and composite structures supported cell adhesion and showed no cytotoxic effect.

Original language	English
Pages (from-to)	4100-4104
Number of pages	5
Journal	ACS Applied Bio Materials
Volume	6
Issue number	10
DOIs	https://doi.org/10.1021/acsabm.3c00557
Publication status	Published - 16 Oct 2023

Keywords

Cardiac patch
conductive biomaterial
extracellular matrix
multiwalled carbon nanotubes
poly(glycerol-sebacate)

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10.1021/acsabm.3c00557

Cite this

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title = "Extracellular Matrix-Based Conductive Composites for Myocardial Tissue Regeneration",

abstract = "Myocardial tissue engineering strategies such as fabrication of cardiac patches for tissue regeneration offer various solutions for the loss of function developed due to myocardial infarction. Here, we combined the hybrid structure (previously obtained and combined decellularized myocardium grafts with poly(glycerol-sebacate) polymer) with multiwalled carbon nanotubes (MWCNTs) to provide the essential characteristics for cardiac tissue regeneration. MWCNTs were doped in the cross-linked structure, and the conductivity and Young{\textquoteright}s modulus of the composite elastomer were found as 5 × 10-3 ± 1 × 10-3 S/m and 374 ± 75.8 kPa, respectively. The cell-material interaction was evaluated, and composite structures supported cell adhesion and showed no cytotoxic effect.",

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doi = "10.1021/acsabm.3c00557",

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AU - Günal, Gülçin

AU - Gokcen, Dincer

AU - Aydin, Halil Murat

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Y1 - 2023/10/16

N2 - Myocardial tissue engineering strategies such as fabrication of cardiac patches for tissue regeneration offer various solutions for the loss of function developed due to myocardial infarction. Here, we combined the hybrid structure (previously obtained and combined decellularized myocardium grafts with poly(glycerol-sebacate) polymer) with multiwalled carbon nanotubes (MWCNTs) to provide the essential characteristics for cardiac tissue regeneration. MWCNTs were doped in the cross-linked structure, and the conductivity and Young’s modulus of the composite elastomer were found as 5 × 10-3 ± 1 × 10-3 S/m and 374 ± 75.8 kPa, respectively. The cell-material interaction was evaluated, and composite structures supported cell adhesion and showed no cytotoxic effect.

AB - Myocardial tissue engineering strategies such as fabrication of cardiac patches for tissue regeneration offer various solutions for the loss of function developed due to myocardial infarction. Here, we combined the hybrid structure (previously obtained and combined decellularized myocardium grafts with poly(glycerol-sebacate) polymer) with multiwalled carbon nanotubes (MWCNTs) to provide the essential characteristics for cardiac tissue regeneration. MWCNTs were doped in the cross-linked structure, and the conductivity and Young’s modulus of the composite elastomer were found as 5 × 10-3 ± 1 × 10-3 S/m and 374 ± 75.8 kPa, respectively. The cell-material interaction was evaluated, and composite structures supported cell adhesion and showed no cytotoxic effect.

KW - Cardiac patch

KW - conductive biomaterial

KW - extracellular matrix

KW - multiwalled carbon nanotubes

KW - poly(glycerol-sebacate)

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DO - 10.1021/acsabm.3c00557

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Extracellular Matrix-Based Conductive Composites for Myocardial Tissue Regeneration

Abstract

Keywords

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