Evaluation of the analgesic and anti-inflammatory activities of some thiazolo[4,5-d]pyrimidines

Ayla Balkan; Zafer Gören; Hüsne Urgun; Ünsal Çaliş; A. Nur Çakar; Pergin Atilla; Tayfun Uzbay

doi:10.1055/s-0031-1299915

Evaluation of the analgesic and anti-inflammatory activities of some thiazolo[4,5-d]pyrimidines

Ayla Balkan
, Zafer Gören
, Hüsne Urgun
, Ünsal Çaliş
, A. Nur Çakar
, Pergin Atilla
, Tayfun Uzbay

Division of Histology and Embryology (Medicine)

Hacettepe University

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Some thiazolo[4,5-d]pyrimidine-7(6H)-one derivatives were evaluated in vivo for their analgesic and anti-inflammatory activities. The results were compared with that of acetyl salicylic acid and phenylbutazone. Compounds 3b and 3h were the most active in the anti-inflammatory paw edema inhibition test. In terms of the analgesic activity (acetic acid writhing test), the most active compound was 2a followed by 31. The most active members of the series were investigated for their ED₅₀ values and ulcerogenic potential.

Original language	English
Pages (from-to)	462-467
Number of pages	6
Journal	Arzneimittel-Forschung/Drug Research
Volume	52
Issue number	6
DOIs	https://doi.org/10.1055/s-0031-1299915
Publication status	Published - 2002

Keywords

Anti-inflammatories, non-steroidal
Thiazolo[4,5-d]pyrimidines, analgesic activity, anti-inflammatory activity

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10.1055/s-0031-1299915

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abstract = "Some thiazolo[4,5-d]pyrimidine-7(6H)-one derivatives were evaluated in vivo for their analgesic and anti-inflammatory activities. The results were compared with that of acetyl salicylic acid and phenylbutazone. Compounds 3b and 3h were the most active in the anti-inflammatory paw edema inhibition test. In terms of the analgesic activity (acetic acid writhing test), the most active compound was 2a followed by 31. The most active members of the series were investigated for their ED50 values and ulcerogenic potential.",

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doi = "10.1055/s-0031-1299915",

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T1 - Evaluation of the analgesic and anti-inflammatory activities of some thiazolo[4,5-d]pyrimidines

AU - Balkan, Ayla

AU - Gören, Zafer

AU - Urgun, Hüsne

AU - Çaliş, Ünsal

AU - Çakar, A. Nur

AU - Atilla, Pergin

AU - Uzbay, Tayfun

PY - 2002

Y1 - 2002

N2 - Some thiazolo[4,5-d]pyrimidine-7(6H)-one derivatives were evaluated in vivo for their analgesic and anti-inflammatory activities. The results were compared with that of acetyl salicylic acid and phenylbutazone. Compounds 3b and 3h were the most active in the anti-inflammatory paw edema inhibition test. In terms of the analgesic activity (acetic acid writhing test), the most active compound was 2a followed by 31. The most active members of the series were investigated for their ED50 values and ulcerogenic potential.

AB - Some thiazolo[4,5-d]pyrimidine-7(6H)-one derivatives were evaluated in vivo for their analgesic and anti-inflammatory activities. The results were compared with that of acetyl salicylic acid and phenylbutazone. Compounds 3b and 3h were the most active in the anti-inflammatory paw edema inhibition test. In terms of the analgesic activity (acetic acid writhing test), the most active compound was 2a followed by 31. The most active members of the series were investigated for their ED50 values and ulcerogenic potential.

KW - Anti-inflammatories, non-steroidal

KW - Thiazolo[4,5-d]pyrimidines, analgesic activity, anti-inflammatory activity

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VL - 52

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JO - Arzneimittel-Forschung/Drug Research

JF - Arzneimittel-Forschung/Drug Research

IS - 6

ER -

Evaluation of the analgesic and anti-inflammatory activities of some thiazolo[4,5-d]pyrimidines

Abstract

Keywords

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