Evaluation of liver damage after application of TVE in the rat model

G. Darilmaz; S. Topaloglu; E. Topaloglu; H. Ozel; O. Saygun; F. M. Avsar; C. Sokmensuer; G. Ucar; M. Sahin; S. Hengirmen

doi:10.1016/j.transproceed.2005.11.002

Evaluation of liver damage after application of TVE in the rat model

G. Darilmaz
, S. Topaloglu
, E. Topaloglu
, H. Ozel
, O. Saygun
, F. M. Avsar
, C. Sokmensuer
, G. Ucar
, M. Sahin
, S. Hengirmen

Division of Medical Pathology

Ankara Numune Education and Research Hospital
Hacettepe University
Kirikkale University
Selcuk University

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Introduction. The aim of this study was to investigate the effects of total vascular exclusion (TVE) on the liver during the early period of reperfusion. Materials and methods. Forty Wistar-Albino rats were divided into four groups. Portal pedicle clamping (groups 1 and 2) or TVE (groups 3 and 4) were applied for 10 minutes. Samples were collected at the time of clamp release (groups 1 and 3) and at 30 minutes of reperfusion (groups 2 and 4). We examined oxidative injury to and histopathology of the liver. Results. Oxidative stress was more prominent with TVE application. Significant alterations were shown in hepatic superoxide dismutase, catalase, glutathione, and glutathione S-transferase levels. The levels of malondialdehyde and myeloperoxidase were not altered significantly. Conclusion. Inflow-outflow occlusion of the liver causes more oxidative stress compared with inflow occlusion.

Original language	English
Pages (from-to)	4550-4552
Number of pages	3
Journal	Transplantation Proceedings
Volume	37
Issue number	10
DOIs	https://doi.org/10.1016/j.transproceed.2005.11.002
Publication status	Published - Dec 2005

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10.1016/j.transproceed.2005.11.002

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title = "Evaluation of liver damage after application of TVE in the rat model",

abstract = "Introduction. The aim of this study was to investigate the effects of total vascular exclusion (TVE) on the liver during the early period of reperfusion. Materials and methods. Forty Wistar-Albino rats were divided into four groups. Portal pedicle clamping (groups 1 and 2) or TVE (groups 3 and 4) were applied for 10 minutes. Samples were collected at the time of clamp release (groups 1 and 3) and at 30 minutes of reperfusion (groups 2 and 4). We examined oxidative injury to and histopathology of the liver. Results. Oxidative stress was more prominent with TVE application. Significant alterations were shown in hepatic superoxide dismutase, catalase, glutathione, and glutathione S-transferase levels. The levels of malondialdehyde and myeloperoxidase were not altered significantly. Conclusion. Inflow-outflow occlusion of the liver causes more oxidative stress compared with inflow occlusion.",

author = "G. Darilmaz and S. Topaloglu and E. Topaloglu and H. Ozel and O. Saygun and Avsar, \{F. M.\} and C. Sokmensuer and G. Ucar and M. Sahin and S. Hengirmen",

year = "2005",

month = dec,

doi = "10.1016/j.transproceed.2005.11.002",

language = "English",

volume = "37",

pages = "4550--4552",

journal = "Transplantation Proceedings",

issn = "0041-1345",

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TY - JOUR

T1 - Evaluation of liver damage after application of TVE in the rat model

AU - Darilmaz, G.

AU - Topaloglu, S.

AU - Topaloglu, E.

AU - Ozel, H.

AU - Saygun, O.

AU - Avsar, F. M.

AU - Sokmensuer, C.

AU - Ucar, G.

AU - Sahin, M.

AU - Hengirmen, S.

PY - 2005/12

Y1 - 2005/12

N2 - Introduction. The aim of this study was to investigate the effects of total vascular exclusion (TVE) on the liver during the early period of reperfusion. Materials and methods. Forty Wistar-Albino rats were divided into four groups. Portal pedicle clamping (groups 1 and 2) or TVE (groups 3 and 4) were applied for 10 minutes. Samples were collected at the time of clamp release (groups 1 and 3) and at 30 minutes of reperfusion (groups 2 and 4). We examined oxidative injury to and histopathology of the liver. Results. Oxidative stress was more prominent with TVE application. Significant alterations were shown in hepatic superoxide dismutase, catalase, glutathione, and glutathione S-transferase levels. The levels of malondialdehyde and myeloperoxidase were not altered significantly. Conclusion. Inflow-outflow occlusion of the liver causes more oxidative stress compared with inflow occlusion.

AB - Introduction. The aim of this study was to investigate the effects of total vascular exclusion (TVE) on the liver during the early period of reperfusion. Materials and methods. Forty Wistar-Albino rats were divided into four groups. Portal pedicle clamping (groups 1 and 2) or TVE (groups 3 and 4) were applied for 10 minutes. Samples were collected at the time of clamp release (groups 1 and 3) and at 30 minutes of reperfusion (groups 2 and 4). We examined oxidative injury to and histopathology of the liver. Results. Oxidative stress was more prominent with TVE application. Significant alterations were shown in hepatic superoxide dismutase, catalase, glutathione, and glutathione S-transferase levels. The levels of malondialdehyde and myeloperoxidase were not altered significantly. Conclusion. Inflow-outflow occlusion of the liver causes more oxidative stress compared with inflow occlusion.

UR - https://www.scopus.com/pages/publications/29544432486

U2 - 10.1016/j.transproceed.2005.11.002

DO - 10.1016/j.transproceed.2005.11.002

M3 - Article

C2 - 16387167

AN - SCOPUS:29544432486

SN - 0041-1345

VL - 37

SP - 4550

EP - 4552

JO - Transplantation Proceedings

JF - Transplantation Proceedings

IS - 10

ER -

Evaluation of liver damage after application of TVE in the rat model

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