Evaluation of bioactivities of chlorokojic acid derivatives against dermatophytes couplet with cytotoxicity

Mutlu Dilsiz Aytemir; Berrin Özçelik; Gülşah Karakaya

doi:10.1016/j.bmcl.2013.03.098

Evaluation of bioactivities of chlorokojic acid derivatives against dermatophytes couplet with cytotoxicity

Mutlu Dilsiz Aytemir
, Berrin Özçelik
, Gülşah Karakaya

Division of Pharmaceutical Chemistry (Pharmacy)

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

In an attempt to find novel antifungal agents with improved activity, a series of compounds bearing 6-chloromethyl-3-hydroxy-2-substituted 4H-pyran-4-one moiety were synthesized and examined for their cytotoxic evaluation and antifungal activities against both standard and isolated dermatophytic fungal species Microsporum gypseum, Trichophyton mentagrophytes var. erinacei and Epidermophyton floccosum.

Original language	English
Pages (from-to)	3646-3649
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	23
Issue number	12
DOIs	https://doi.org/10.1016/j.bmcl.2013.03.098
Publication status	Published - 15 Jun 2013

Keywords

Antidermatophytic activity
Chlorokojic acid
Cytotoxicity
Mannich base
Synthesis

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10.1016/j.bmcl.2013.03.098

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abstract = "In an attempt to find novel antifungal agents with improved activity, a series of compounds bearing 6-chloromethyl-3-hydroxy-2-substituted 4H-pyran-4-one moiety were synthesized and examined for their cytotoxic evaluation and antifungal activities against both standard and isolated dermatophytic fungal species Microsporum gypseum, Trichophyton mentagrophytes var. erinacei and Epidermophyton floccosum.",

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AU - Aytemir, Mutlu Dilsiz

AU - Özçelik, Berrin

AU - Karakaya, Gülşah

PY - 2013/6/15

Y1 - 2013/6/15

N2 - In an attempt to find novel antifungal agents with improved activity, a series of compounds bearing 6-chloromethyl-3-hydroxy-2-substituted 4H-pyran-4-one moiety were synthesized and examined for their cytotoxic evaluation and antifungal activities against both standard and isolated dermatophytic fungal species Microsporum gypseum, Trichophyton mentagrophytes var. erinacei and Epidermophyton floccosum.

AB - In an attempt to find novel antifungal agents with improved activity, a series of compounds bearing 6-chloromethyl-3-hydroxy-2-substituted 4H-pyran-4-one moiety were synthesized and examined for their cytotoxic evaluation and antifungal activities against both standard and isolated dermatophytic fungal species Microsporum gypseum, Trichophyton mentagrophytes var. erinacei and Epidermophyton floccosum.

KW - Antidermatophytic activity

KW - Chlorokojic acid

KW - Cytotoxicity

KW - Mannich base

KW - Synthesis

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SN - 0960-894X

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 12

ER -

Evaluation of bioactivities of chlorokojic acid derivatives against dermatophytes couplet with cytotoxicity

Abstract

Keywords

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