Ethyl 2,7,7-trimethyl-4-(1-methyl-1H-indol-3-yl)-5-oxo-1,4,5,6,7,8- hexahydroquinoline-3-carboxylate

Sema Öztürk Yildirim; Ray J. Butcher; Miyase Gözde Gündüz; Ahmed El-Khouly; Rahime Şimşek; Cihat Şafak

doi:10.1107/S1600536812047976

Ethyl 2,7,7-trimethyl-4-(1-methyl-1H-indol-3-yl)-5-oxo-1,4,5,6,7,8- hexahydroquinoline-3-carboxylate

Sema Öztürk Yildirim
, Ray J. Butcher
, Miyase Gözde Gündüz
, Ahmed El-Khouly
, Rahime Şimşek
, Cihat Şafak

Division of Pharmaceutical Chemistry (Pharmacy)

Howard University
Erciyes University
Hacettepe University

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

In the title molecule, C₂₄H₂₈N₂O ₃, the cyclohexene ring is in a sofa conformation and the 1,4-dihydropyridine ring is in a slight boat conformation. In the indole ring system, the pyrrole and benzene rings form a dihedral angle of 2.63 14;(7)°. In the crystal, N - HO hydrogen bonds connect the molecules into C(6) chains parallel to the b axis and pairs of weak C - HO hydrogen bonds link inversion-related chains into a ladder motif through R 2 ²(18) rings. A weak intramolecular C - HO hydrogen bond is also observed.

Original language	English
Pages (from-to)	o40-o41
Journal	Acta Crystallographica Section E: Structure Reports Online
Volume	69
Issue number	1
DOIs	https://doi.org/10.1107/S1600536812047976
Publication status	Published - Jan 2013

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title = "Ethyl 2,7,7-trimethyl-4-(1-methyl-1H-indol-3-yl)-5-oxo-1,4,5,6,7,8- hexahydroquinoline-3-carboxylate",

abstract = "In the title molecule, C24H28N2O 3, the cyclohexene ring is in a sofa conformation and the 1,4-dihydropyridine ring is in a slight boat conformation. In the indole ring system, the pyrrole and benzene rings form a dihedral angle of 2.63 14;(7)°. In the crystal, N - HO hydrogen bonds connect the molecules into C(6) chains parallel to the b axis and pairs of weak C - HO hydrogen bonds link inversion-related chains into a ladder motif through R 2 2(18) rings. A weak intramolecular C - HO hydrogen bond is also observed.",

author = "\{{\"O}zt{\"u}rk Yildirim\}, Sema and Butcher, \{Ray J.\} and G{\"u}nd{\"u}z, \{Miyase G{\"o}zde\} and Ahmed El-Khouly and Rahime {\c S}im{\c s}ek and Cihat {\c S}afak",

year = "2013",

month = jan,

doi = "10.1107/S1600536812047976",

language = "English",

volume = "69",

pages = "o40--o41",

journal = "Acta Crystallographica Section E: Structure Reports Online",

issn = "1600-5368",

publisher = "International Union of Crystallography",

number = "1",

}

TY - JOUR

T1 - Ethyl 2,7,7-trimethyl-4-(1-methyl-1H-indol-3-yl)-5-oxo-1,4,5,6,7,8- hexahydroquinoline-3-carboxylate

AU - Öztürk Yildirim, Sema

AU - Butcher, Ray J.

AU - Gündüz, Miyase Gözde

AU - El-Khouly, Ahmed

AU - Şimşek, Rahime

AU - Şafak, Cihat

PY - 2013/1

Y1 - 2013/1

N2 - In the title molecule, C24H28N2O 3, the cyclohexene ring is in a sofa conformation and the 1,4-dihydropyridine ring is in a slight boat conformation. In the indole ring system, the pyrrole and benzene rings form a dihedral angle of 2.63 14;(7)°. In the crystal, N - HO hydrogen bonds connect the molecules into C(6) chains parallel to the b axis and pairs of weak C - HO hydrogen bonds link inversion-related chains into a ladder motif through R 2 2(18) rings. A weak intramolecular C - HO hydrogen bond is also observed.

AB - In the title molecule, C24H28N2O 3, the cyclohexene ring is in a sofa conformation and the 1,4-dihydropyridine ring is in a slight boat conformation. In the indole ring system, the pyrrole and benzene rings form a dihedral angle of 2.63 14;(7)°. In the crystal, N - HO hydrogen bonds connect the molecules into C(6) chains parallel to the b axis and pairs of weak C - HO hydrogen bonds link inversion-related chains into a ladder motif through R 2 2(18) rings. A weak intramolecular C - HO hydrogen bond is also observed.

UR - https://www.scopus.com/pages/publications/84872042227

U2 - 10.1107/S1600536812047976

DO - 10.1107/S1600536812047976

M3 - Article

C2 - 23476426

AN - SCOPUS:84872042227

SN - 1600-5368

VL - 69

SP - o40-o41

JO - Acta Crystallographica Section E: Structure Reports Online

JF - Acta Crystallographica Section E: Structure Reports Online

IS - 1

ER -

Ethyl 2,7,7-trimethyl-4-(1-methyl-1H-indol-3-yl)-5-oxo-1,4,5,6,7,8- hexahydroquinoline-3-carboxylate

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