Eriskin selulitinde mikrobiyolojik degerlendirme, notrofil kemotaksisi ve non-steroidal antiinflamatuvar ilac kullanimi

Background and design. Although cellulitis is known to be a bacterial infection etiologic agent has been isolated only in a small percentage of the patients. Acute bacterial infections alter the activity of neutrophils, but neutrophil chemotaxis in cellulitis has not been investigated so far. Fifteen adult patients with cellulitis without underlying disease were included in the study. Fine needle aspiration was used for microbiologic evaluation. Nine patients received NSAID and an antimicrobial agent, while 6 patients received placebo. In 11 of 15 patients and 17 healthy controls, chemotaxis, random migration and chemotactic index were evaluated before and after treatment. Results. Positive aspiration rate was found to be 6.6%. When neutrophil chemotaxis, random migration, chemotactic index values of 11 patients before and after treatment were compared to 17 healthy controls no statistically significant difference was seen (p > 0.05). Again there was no statistically significant between the two treatment groups when their recovery time were compared (p > 0.05). Conclusion. We found low positive aspiration rate as reported previously. The lack of alteration in neutrophil chemotaxis leads us to speculate that cellulitis is not a real infectious disease. On the other hand, NSAIDs do not seem to alter the course of cellulitis.