Abstract
The aim of this study was to investigate whether nonsteroidal antiinflammatory drugs (NSAIDs) such as ibuprofen (IBU), indomethacin (INDO), aspirin (ASP), and celecoxib (CEL) could enhance the susceptibility the oxidative stress caused by the acute intoxication with ethanol in gastric mucosa, liver and brain of mice. The results showed that only the IBU treatment contribute to the control of the lipid peroxidation (LPO) and thiol group levels in all tissues. However, CEL can be able to increase the susceptibility of gastric mucosa to ethanol-induced oxidative stress like classic NSAIDs. while it has a significant protective effect in brain tissue..
| Original language | English |
|---|---|
| Pages (from-to) | 107-112 |
| Number of pages | 6 |
| Journal | Acta Pharmaceutica Turcica |
| Volume | 46 |
| Issue number | 2 |
| Publication status | Published - 2004 |
Keywords
- COX-2 inhibitors
- Lipid peroxidation
- Nonsteroidal antiinflammatory drugs
- Reduced glutathione
- Total thiol groups
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