Effect of selenium on ischemic and reperfusion injury in isolated guinea pig lungs

Deniz Erbaş; Halim Soncul; Nurten Türkozkan; Aysel Arioioglu; Sevda Müftüoǧlu; Ali Ersöz

doi:10.1016/0306-3623(95)00027-5

Effect of selenium on ischemic and reperfusion injury in isolated guinea pig lungs

Deniz Erbaş
, Halim Soncul
, Nurten Türkozkan
, Aysel Arioioglu
, Sevda Müftüoǧlu
, Ali Ersöz

Gazi University

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

1. 1. An experimental comparative study on isolated guinea pig lungs was carried out to determine the effect of selenium added to pulmoplegic solution on ischemic lung preservation. 2. 2. Two different types of solutions (Eurocollins in control group and Eurocollins + selenium 10^-3 M in experimental group) were infused before 3 hr of normothermic ischemia. 3. 3. Tissue malone dialdehyde (MDA) and tissue glutathione (GSH) levels were assessed before the ischemic period, after the ischemia and at the end of reperfusion. Electron microscopic changes were also studied at the end of reperfusion to compare the cellular injury between the groups. 4. 4. Addition of selenium before the ischemic period relatively decreased tissue MDA levels after reperfusion but did not alter tissue GSH levels.

Original language	English
Pages (from-to)	1669-1672
Number of pages	4
Journal	General Pharmacology: The Vascular System
Volume	26
Issue number	8
DOIs	https://doi.org/10.1016/0306-3623(95)00027-5
Publication status	Published - Dec 1995
Externally published	Yes

Keywords

Glutathione
ischemic injury
reperfusion injury
selenium

Access to Document

10.1016/0306-3623(95)00027-5

Cite this

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title = "Effect of selenium on ischemic and reperfusion injury in isolated guinea pig lungs",

abstract = "1. 1. An experimental comparative study on isolated guinea pig lungs was carried out to determine the effect of selenium added to pulmoplegic solution on ischemic lung preservation. 2. 2. Two different types of solutions (Eurocollins in control group and Eurocollins + selenium 10-3 M in experimental group) were infused before 3 hr of normothermic ischemia. 3. 3. Tissue malone dialdehyde (MDA) and tissue glutathione (GSH) levels were assessed before the ischemic period, after the ischemia and at the end of reperfusion. Electron microscopic changes were also studied at the end of reperfusion to compare the cellular injury between the groups. 4. 4. Addition of selenium before the ischemic period relatively decreased tissue MDA levels after reperfusion but did not alter tissue GSH levels.",

keywords = "Glutathione, ischemic injury, reperfusion injury, selenium",

author = "Deniz Erba{\c s} and Halim Soncul and Nurten T{\"u}rkozkan and Aysel Arioioglu and Sevda M{\"u}ft{\"u}oǧlu and Ali Ers{\"o}z",

year = "1995",

month = dec,

doi = "10.1016/0306-3623(95)00027-5",

language = "English",

volume = "26",

pages = "1669--1672",

journal = "General Pharmacology: The Vascular System",

issn = "0306-3623",

publisher = "Elsevier B.V.",

number = "8",

}

TY - JOUR

T1 - Effect of selenium on ischemic and reperfusion injury in isolated guinea pig lungs

AU - Erbaş, Deniz

AU - Soncul, Halim

AU - Türkozkan, Nurten

AU - Arioioglu, Aysel

AU - Müftüoǧlu, Sevda

AU - Ersöz, Ali

PY - 1995/12

Y1 - 1995/12

N2 - 1. 1. An experimental comparative study on isolated guinea pig lungs was carried out to determine the effect of selenium added to pulmoplegic solution on ischemic lung preservation. 2. 2. Two different types of solutions (Eurocollins in control group and Eurocollins + selenium 10-3 M in experimental group) were infused before 3 hr of normothermic ischemia. 3. 3. Tissue malone dialdehyde (MDA) and tissue glutathione (GSH) levels were assessed before the ischemic period, after the ischemia and at the end of reperfusion. Electron microscopic changes were also studied at the end of reperfusion to compare the cellular injury between the groups. 4. 4. Addition of selenium before the ischemic period relatively decreased tissue MDA levels after reperfusion but did not alter tissue GSH levels.

AB - 1. 1. An experimental comparative study on isolated guinea pig lungs was carried out to determine the effect of selenium added to pulmoplegic solution on ischemic lung preservation. 2. 2. Two different types of solutions (Eurocollins in control group and Eurocollins + selenium 10-3 M in experimental group) were infused before 3 hr of normothermic ischemia. 3. 3. Tissue malone dialdehyde (MDA) and tissue glutathione (GSH) levels were assessed before the ischemic period, after the ischemia and at the end of reperfusion. Electron microscopic changes were also studied at the end of reperfusion to compare the cellular injury between the groups. 4. 4. Addition of selenium before the ischemic period relatively decreased tissue MDA levels after reperfusion but did not alter tissue GSH levels.

KW - Glutathione

KW - ischemic injury

KW - reperfusion injury

KW - selenium

UR - https://www.scopus.com/pages/publications/0029612312

U2 - 10.1016/0306-3623(95)00027-5

DO - 10.1016/0306-3623(95)00027-5

M3 - Article

C2 - 8745154

AN - SCOPUS:0029612312

SN - 0306-3623

VL - 26

SP - 1669

EP - 1672

JO - General Pharmacology: The Vascular System

JF - General Pharmacology: The Vascular System

IS - 8

ER -

Effect of selenium on ischemic and reperfusion injury in isolated guinea pig lungs

Abstract

Keywords

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