Duration of intensive care unit stay as a guide for the timely treatment of Carbapenem-resistant Enterobacterales bloodstream infection: a case-control study

Eda Karadoǧan; Hanife Uzar; Asll Özden; Büşra Dalglç; Mervenur Demir; Ahmet Sertçelik; Gülçin Telli Dizman; Banu Çaklr; Gülşen Hazlrolan; Omrum Uzun; Gökhan Metan

doi:10.1017/ash.2025.10198

Duration of intensive care unit stay as a guide for the timely treatment of Carbapenem-resistant Enterobacterales bloodstream infection: a case-control study

Eda Karadoǧan
, Hanife Uzar
, Asll Özden
, Büşra Dalglç
, Mervenur Demir
, Ahmet Sertçelik
, Gülçin Telli Dizman
, Banu Çaklr
, Gülşen Hazlrolan
, Omrum Uzun
, Gökhan Metan

Hacettepe University

Research output: Contribution to journal › Article › peer-review

Abstract

Timely selection of appropriate empirical treatment for carbapenem-resistant Enterobacterales (CRE) bacteremia remains challenging, especially when prior antibiotic exposure data is unavailable. We found that intensive care unit stay duration predicts CRE bacteremia - with ≥8 days showing 81% sensitivity and 96% PPV - providing a practical clue for empirical therapy decisions.

Original language	English
Article number	e276
Journal	Antimicrobial Stewardship and Healthcare Epidemiology
Volume	5
Issue number	1
DOIs	https://doi.org/10.1017/ash.2025.10198
Publication status	Published - 20 Oct 2025

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10.1017/ash.2025.10198

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Karadoǧan, E., Uzar, H., Özden, A., Dalglç, B., Demir, M., Sertçelik, A., Telli Dizman, G., Çaklr, B., Hazlrolan, G., Uzun, O., & Metan, G. (2025). Duration of intensive care unit stay as a guide for the timely treatment of Carbapenem-resistant Enterobacterales bloodstream infection: a case-control study. Antimicrobial Stewardship and Healthcare Epidemiology, 5(1), Article e276. https://doi.org/10.1017/ash.2025.10198

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title = "Duration of intensive care unit stay as a guide for the timely treatment of Carbapenem-resistant Enterobacterales bloodstream infection: a case-control study",

abstract = "Timely selection of appropriate empirical treatment for carbapenem-resistant Enterobacterales (CRE) bacteremia remains challenging, especially when prior antibiotic exposure data is unavailable. We found that intensive care unit stay duration predicts CRE bacteremia - with ≥8 days showing 81\% sensitivity and 96\% PPV - providing a practical clue for empirical therapy decisions.",

author = "Eda Karadoǧan and Hanife Uzar and Asll {\"O}zden and B{\"u}{\c s}ra Dalgl{\c c} and Mervenur Demir and Ahmet Sert{\c c}elik and \{Telli Dizman\}, G{\"u}l{\c c}in and Banu {\c C}aklr and G{\"u}l{\c s}en Hazlrolan and Omrum Uzun and G{\"o}khan Metan",

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Karadoǧan, E, Uzar, H, Özden, A, Dalglç, B, Demir, M, Sertçelik, A, Telli Dizman, G, Çaklr, B, Hazlrolan, G , Uzun, O & Metan, G 2025, 'Duration of intensive care unit stay as a guide for the timely treatment of Carbapenem-resistant Enterobacterales bloodstream infection: a case-control study', Antimicrobial Stewardship and Healthcare Epidemiology, vol. 5, no. 1, e276. https://doi.org/10.1017/ash.2025.10198

Duration of intensive care unit stay as a guide for the timely treatment of Carbapenem-resistant Enterobacterales bloodstream infection: a case-control study. / Karadoǧan, Eda; Uzar, Hanife; Özden, Asll et al.
In: Antimicrobial Stewardship and Healthcare Epidemiology, Vol. 5, No. 1, e276, 20.10.2025.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Duration of intensive care unit stay as a guide for the timely treatment of Carbapenem-resistant Enterobacterales bloodstream infection

T2 - a case-control study

AU - Karadoǧan, Eda

AU - Uzar, Hanife

AU - Özden, Asll

AU - Dalglç, Büşra

AU - Demir, Mervenur

AU - Sertçelik, Ahmet

AU - Telli Dizman, Gülçin

AU - Çaklr, Banu

AU - Hazlrolan, Gülşen

AU - Uzun, Omrum

AU - Metan, Gökhan

PY - 2025/10/20

Y1 - 2025/10/20

N2 - Timely selection of appropriate empirical treatment for carbapenem-resistant Enterobacterales (CRE) bacteremia remains challenging, especially when prior antibiotic exposure data is unavailable. We found that intensive care unit stay duration predicts CRE bacteremia - with ≥8 days showing 81% sensitivity and 96% PPV - providing a practical clue for empirical therapy decisions.

AB - Timely selection of appropriate empirical treatment for carbapenem-resistant Enterobacterales (CRE) bacteremia remains challenging, especially when prior antibiotic exposure data is unavailable. We found that intensive care unit stay duration predicts CRE bacteremia - with ≥8 days showing 81% sensitivity and 96% PPV - providing a practical clue for empirical therapy decisions.

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DO - 10.1017/ash.2025.10198

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JO - Antimicrobial Stewardship and Healthcare Epidemiology

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IS - 1

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ER -

Duration of intensive care unit stay as a guide for the timely treatment of Carbapenem-resistant Enterobacterales bloodstream infection: a case-control study

Abstract

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