Abstract
22 Novel pyridazin-3-ones have been designed for anti-hepatitis B virus (HBV) activity by structural modifications of 3711 which is capsid assembly modulator. Structure of the target compounds were confirmed by elemental analysis and spectroscopic data including X-ray studies. Among them, the compound having piperazine moiety showed notable inhibitory activity on secretion of HBV DNA and HBeAg which is comparable to that of AT-130. The preliminary structure-activity relationships (SARs) of the newly synthesized pyridazin-3-one analogues were summarized, which may help researchers to discover more potent anti-HBV agents bearing pyridazine-3-one scaffold.
| Original language | English |
|---|---|
| Article number | e202203164 |
| Journal | ChemistrySelect |
| Volume | 7 |
| Issue number | 40 |
| DOIs | |
| Publication status | Published - 26 Oct 2022 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Anti-Hepatitis B virus activity
- capsid assembly modulators
- pyridazin-3-one
- synthesis
- x-ray analysis
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