@inbook{b87bd1f2629446669ae298b5c2516040,
title = "Contributions of 12/15-Lipoxygenase to Bleeding in the Brain Following Ischemic Stroke",
abstract = "Ischemic strokes are caused by one or more blood clots that typically obstruct one of the major arteries in the brain, but frequently also result in leakage of the blood-brain barrier and subsequent hemorrhage. While it has long been known that the enzyme 12/15-lipoxygenase (12/15-LOX) is up-regulated following ischemic strokes and contributes to neuronal cell death, recent research has shown an additional major role for 12/15-LOX in causing this hemorrhagic transformation. These findings have important implications for the use of 12/15-LOX inhibitors in the treatment of stroke.",
keywords = "12-HETE, 15-HETE, Blood-brain barrier, Eicosanoid, Hemorrhage, Hemorrhagic transformation, Ischemia, Ischemic stroke, Lipoxygenase, Neuroprotection, STAT6, Tissue plasminogen activator, Warfarin, tPA",
author = "Yi Zheng and Yu Liu and Hulya Karatas and Kazim Yigitkanli and Holman, \{Theodore R.\} and \{van Leyen\}, Klaus",
note = "Publisher Copyright: {\textcopyright} 2019, Springer Nature Switzerland AG.",
year = "2019",
doi = "10.1007/978-3-030-21735-8\_12",
language = "English",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer New York LLC",
pages = "125--131",
booktitle = "Advances in Experimental Medicine and Biology",
}